RRC ID 36978
著者 Nishiwada S, Sho M, Yasuda S, Shimada K, Yamato I, Akahori T, Kinoshita S, Nagai M, Konishi N, Nakajima Y.
タイトル Clinical significance of CD155 expression in human pancreatic cancer.
ジャーナル Anticancer Res
Abstract BACKGROUND/AIM:CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer.
MATERIALS AND METHODS:We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined.
RESULTS:CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. Tumor CD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expression and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G2/M phase in pancreatic cancer cells.
CONCLUSION:CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy.
巻・号 35(4)
ページ 2287-97
公開日 2015-4-1
PII 35/4/2287
PMID 25862891
MeSH Aged Biomarkers, Tumor / biosynthesis* Biomarkers, Tumor / immunology Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Neoplasm Staging Neovascularization, Pathologic / genetics* Neovascularization, Pathologic / pathology Pancreatic Neoplasms / genetics* Pancreatic Neoplasms / immunology Pancreatic Neoplasms / pathology Prognosis Receptors, Virus / biosynthesis* Receptors, Virus / genetics Receptors, Virus / immunology Vascular Endothelial Growth Factor A / genetics
IF 1.994
引用数 47
WOS 分野 ONCOLOGY
リソース情報
ヒト・動物細胞 MIA Paca2(RCB2094) PANC-1(RCB2095)