RRC ID 37079
著者 Aikawa T, Ito S, Shinohara M, Kaneko M, Kondo T, Yuasa M.
タイトル A drug formulation using an alginate hydrogel matrix for efficient oral delivery of the manganese porphyrin-based superoxide dismutase mimic.
ジャーナル Biomater Sci
Abstract In order for patients to avail of the therapeutic benefits of antioxidant drugs efficiently and conveniently, a robust oral delivery system needs to be developed. However, a common problem in oral drug delivery is ensuring that the drug remains functionally intact even after it has passed through the acidic environment of the gastrointestinal (GI) tract. To protect drugs within the GI environment, we formulated a design based on encapsulating liposomal drugs by using an alginate matrix as a carrier. The liposomal drug was composed of manganese porphyrin (Mn-por), which has been developed as a mimic of superoxide dismutase (SOD), as the therapeutic agent based on the antioxidative effect, namely superoxide (O2˙(-)) inhibitory activity. A cytochrome c assay revealed that the O2˙(-) inhibitory activity of Mn-por could be maintained even after treatment with simulated gastric and intestinal fluids. We demonstrated that oral administration of the formulated drug significantly inhibited the growth of transplanted tumors in mice. The drug formulation presented in this study would be a good candidate for orally available systems, which can effectively deliver SOD mimics.
巻・号 3(6)
ページ 861-9
公開日 2015-6-1
DOI 10.1039/c5bm00056d
PMID 26221846
MeSH Administration, Oral Alginates / chemistry* Animals Antioxidants / administration & dosage* Antioxidants / chemistry* Chemistry, Pharmaceutical Drug Delivery Systems Glucuronic Acid / chemistry Hexuronic Acids / chemistry Humans Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry* Liposomes Manganese / chemistry* Metalloporphyrins / administration & dosage* Metalloporphyrins / chemistry* Mice Superoxide Dismutase / administration & dosage* Superoxide Dismutase / chemistry* Superoxide Dismutase / metabolism
IF 6.183
引用数 13
WOS 分野 MATERIALS SCIENCE, BIOMATERIALS
リソース情報
ヒト・動物細胞 Colon-26(RCB2657)