論文 - 詳細
| RRC ID | 37479 |
|---|---|
| 著者 | Arai MA, Akamine R, Sadhu SK, Ahmed F, Ishibashi M. |
| タイトル | Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum. |
| ジャーナル | J Nat Med |
| Abstract |
The inhibition of the hedgehog (Hh) signaling pathway has emerged as an attractive anti-cancer strategy. As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum. Compounds 1 and 3 showed potent Hh/GLI1-mediated transcriptional inhibitory activity and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compounds 1 and 3 clearly inhibited the Hh signaling pathway by down-regulating the expression of GLI-related proteins (PTCH and BCL2) in DU145 cells. |
| 巻・号 | 69(4) |
| ページ | 538-42 |
| 公開日 | 2015-10-1 |
| DOI | 10.1007/s11418-015-0922-8 |
| PMID | 26026497 |
| MeSH | Crinum / chemistry* Down-Regulation Hedgehog Proteins / chemistry* Humans Plants, Medicinal / chemistry* Signal Transduction Transcription Factors / chemistry* Transcriptional Activation Zinc Finger Protein GLI1 |
| IF | 2.055 |
| 引用数 | 11 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) 10T1/2(RCB0247) |