論文 - 詳細
| RRC ID | 37491 |
|---|---|
| 著者 | Saito T, Ohba S, Yano F, Seto I, Yonehara Y, Takato T, Ogasawara T. |
| タイトル | Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2. |
| ジャーナル | Cell Reprogram |
| Abstract |
Previously, we reported that the transcription factor Nanog, which maintains the self-renewal of embryonic stem cells (ESCs), promotes the osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 through a genome reprogramming process. In the present study, to clarify the mechanism underlying the multipotency of mesenchymal stem cells (MSCs) and to develop a novel approach to bone regenerative medicine, we attempted to identify the downstream effectors of Nanog in promoting osteogenic differentiation of mouse mesenchymal cells. We demonstrated that Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2. |
| 巻・号 | 17(3) |
| ページ | 227-34 |
| 公開日 | 2015-6-1 |
| DOI | 10.1089/cell.2014.0059 |
| PMID | 26053522 |
| PMC | PMC4487263 |
| MeSH | Animals Cell Line Core Binding Factor Alpha 2 Subunit / metabolism* Core Binding Factor Alpha 3 Subunit / metabolism* Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Mesenchymal Stem Cells / metabolism Mesenchymal Stem Cells / physiology* Mice Nanog Homeobox Protein Osteogenesis* Signal Transduction |
| IF | 1.702 |
| 引用数 | 4 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY CELL & TISSUE ENGINEERING GENETICS & HEREDITY |
| リソース情報 | |
| ヒト・動物細胞 | 10T1/2(RCB0247) |