論文 - 詳細
| RRC ID | 37585 |
|---|---|
| 著者 | Uchino K, Okamoto K, Sakai E, Yoneshima E, Iwatake M, Fukuma Y, Nishishita K, Tsukuba T. |
| タイトル | Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation. |
| ジャーナル | Phytother Res |
| Abstract |
Bone is constantly controlled by a balance between osteoblastic bone formation and osteoclastic bone resorption. Liquiritigenin is a plant-derived flavonoid and has various pharmacological effects, such as antioxidative, antitumor, and antiinflammatory effects. Here, we show that liquiritigenin has dual effects on the proliferation of bone cells, regarding the promotion of osteoblast differentiation and the inhibition of osteoclast differentiation. Liquiritigenin-treated murine osteoblastic MC3T3-E1 cells showed an increased alkaline phosphatase activity and enhanced phosphorylation of Smad1/5 compared with untreated cells. Moreover, liquiritigenin inhibited osteoclast differentiation, its bone-resorption activity through slightly decreased the phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and inhibitor of nuclear factor kappa Bα; however, the phosphorylation of Akt and p38 slightly increased in bone marrow-derived osteoclasts. The expression levels of the osteoclast marker proteins nuclear factor of activated T-cell cytoplasmic-1, Src, and cathepsin K diminished. These results suggest that liquiritigenin may be useful as a therapeutic and/or preventive agent for osteoporosis or inflammatory bone diseases. |
| 巻・号 | 29(11) |
| ページ | 1714-21 |
| 公開日 | 2015-11-1 |
| DOI | 10.1002/ptr.5416 |
| PMID | 26172226 |
| MeSH | Animals Bone Resorption / prevention & control Bone and Bones Cell Differentiation / drug effects Cell Line Extracellular Signal-Regulated MAP Kinases / metabolism Flavanones / pharmacology* Flavonoids / pharmacology JNK Mitogen-Activated Protein Kinases / metabolism Mice Osteoblasts / drug effects* Osteoclasts / drug effects* Osteogenesis / drug effects Osteoporosis / drug therapy Phosphorylation RANK Ligand / metabolism |
| IF | 4.087 |
| 引用数 | 6 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |