Reference - Detail
| RRC ID | 37605 |
|---|---|
| Author | Kanda N, Anada T, Handa T, Kobayashi K, Ezoe Y, Takahashi T, Suzuki O. |
| Title | Orthotopic Osteogenecity Enhanced by a Porous Gelatin Sponge in a Critical-Sized Rat Calvaria Defect. |
| Journal | Macromol Biosci |
| Abstract |
The gelatin (Gel) powders, derived from acidic and basic extractions of porcine dermis (referred to as AE and BE), were processed for the porous sponge preparation. The disks, which were less than or greater than 500 μm in diameter [small (S) and large (L) pores, respectively] in both extractions and had an interconnected structure respectively, were implanted in critical-sized defects (CSD) of rat calvaria for 4 and 8 weeks to analyze the bone repair capability. Only the AE-S disk induced bone formation (over 60%) histomorphometrically in the CSD after 8 weeks, although the collagen orientation of the regenerated bone was still immature. Osteoblastic cell culture until 14 days did not substantiate marked superiority of AE-S disk regarding the proliferation and the differentiation, although the initial attachment was enhanced on AE-S disk than BE-L disk. The results provide the findings that a Gel sponge with a specific porous structure is capable of inducing orthotopic bone formation in vivo environment. |
| Volume | 15(12) |
| Pages | 1647-55 |
| Published | 2015-12-1 |
| DOI | 10.1002/mabi.201500191 |
| PMID | 26200698 |
| MeSH | Animals Bone Substitutes* / chemistry Bone Substitutes* / pharmacology Cell Differentiation / drug effects Cell Proliferation / drug effects* Cells, Cultured Gelatin* / chemistry Gelatin* / pharmacology Male Osteoblasts / metabolism* Osteoblasts / pathology Osteogenesis / drug effects* Porosity Rats Rats, Wistar Skull* / injuries Skull* / metabolism Skull* / pathology Swine |
| IF | 3.416 |
| Times Cited | 10 |
| WOS Category | POLYMER SCIENCE BIOCHEMISTRY & MOLECULAR BIOLOGY MATERIALS SCIENCE, BIOMATERIALS |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | ST2(RCB0224) |