論文 - 詳細
| RRC ID | 3761 |
|---|---|
| 著者 | Bacaj T, Tevlin M, Lu Y, Shaham S. |
| タイトル | Glia are essential for sensory organ function in C. elegans. |
| ジャーナル | Science |
| Abstract |
Sensory organs are composed of neurons, which convert environmental stimuli to electrical signals, and glia-like cells, whose functions are not well understood. To decipher glial roles in sensory organs, we ablated the sheath glial cell of the major sensory organ of Caenorhabditis elegans. We found that glia-ablated animals exhibit profound sensory deficits and that glia provide activities that affect neuronal morphology, behavior generation, and neuronal uptake of lipophilic dyes. To understand the molecular bases of these activities, we identified 298 genes whose messenger RNAs are glia-enriched. One gene, fig-1, encodes a labile protein with conserved thrombospondin TSP1 domains. FIG-1 protein functions extracellularly, is essential for neuronal dye uptake, and also affects behavior. Our results suggest that glia are required for multiple aspects of sensory organ function. |
| 巻・号 | 322(5902) |
| ページ | 744-7 |
| 公開日 | 2008-10-31 |
| DOI | 10.1126/science.1163074 |
| PII | 322/5902/744 |
| PMID | 18974354 |
| PMC | PMC2735448 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / analysis Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Calcium / metabolism Carbocyanines / metabolism Chemotaxis Cilia / chemistry Cilia / ultrastructure Fluorescent Dyes / metabolism Gene Expression Genes, Helminth Neuroglia / physiology* Odorants Oligonucleotide Array Sequence Analysis Osmolar Concentration Sense Organs / physiology Sensory Receptor Cells / cytology Sensory Receptor Cells / physiology* Signal Transduction Sodium Chloride Temperature Thrombospondins / chemistry Thrombospondins / genetics Thrombospondins / physiology* Transcription, Genetic |
| IF | 41.846 |
| 引用数 | 103 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| 線虫 | tm2079 |