RRC ID 37751
Author Mino N, Miyahara R, Nakayama E, Takahashi T, Takahashi A, Iwakiri S, Sonobe M, Okubo K, Hirata T, Sehara A, Date H.
Title A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma.
Journal J Surg Oncol
Abstract BACKGROUND AND OBJECTIVES:A disintegrin and metalloprotease 12 (ADAM12) has multiple domains and functions, and it plays important roles in the development of cancer. We conducted a retrospective study to determine whether the expression of the membrane type of ADAM12 (ADAM12-L) could be a prognostic factor in resected pathological (p-) stage I lung adenocarcinoma.
METHODS:ADAM12-L mRNA expression was quantified by a reverse-transcription polymerase chain reaction in tissue samples from 84 completely resected p-stage I lung adenocarcinoma patients. The patients were divided into ADAM12-L-Low and ADAM12-L-High groups, and correlations with clinicopathologic features were obtained.
RESULTS:Five-year survival rates of the ADAM12-L-Low and ADAM12-L-High groups were 95.1% and 71.9%, respectively. The postoperative prognosis for the ADAM12-L-High group was significantly poorer than for the ADAM12-L-Low group (P = 0.006). Multivariate analysis confirmed that high expression of ADAM12-L was an independent factor for poor prognosis (P = 0.007, hazard ratio 8.288). The ADAM12-L-High group was less differentiated and had a significantly higher rate of cancer recurrence.
CONCLUSIONS:ADAM12-L mRNA expression is an independent prognostic factor in resected p-stage I lung adenocarcinoma, and is significantly correlated with tumor differentiation stage and postoperative cancer recurrence.
Volume 100(3)
Pages 267-72
Published 2009-9-1
DOI 10.1002/jso.21313
PMID 19544357
MeSH ADAM Proteins / genetics* ADAM Proteins / metabolism ADAM12 Protein Adenocarcinoma / genetics Adenocarcinoma / mortality* Adenocarcinoma / pathology Adenocarcinoma / surgery Adult Aged Aged, 80 and over Cell Line, Tumor Disintegrins / genetics* Disintegrins / metabolism Female Humans Lung Neoplasms / genetics Lung Neoplasms / mortality* Lung Neoplasms / pathology Lung Neoplasms / surgery Male Membrane Proteins / genetics* Membrane Proteins / metabolism Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Prognosis RNA, Messenger / metabolism Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction
IF 3.114
Times Cited 22
Human and Animal Cells