| RRC ID |
37756
|
| Author |
Mizuno Y, Tokuzawa Y, Ninomiya Y, Yagi K, Yatsuka-Kanesaki Y, Suda T, Fukuda T, Katagiri T, Kondoh Y, Amemiya T, Tashiro H, Okazaki Y.
|
| Title |
miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b.
|
| Journal |
FEBS Lett
|
| Abstract |
Although microRNAs (miRNAs) are involved in many biological processes, the mechanisms whereby miRNAs regulate osteoblastic differentiation are poorly understood. Here, we found that BMP-4-induced osteoblastic differentiation of bone marrow-derived ST2 stromal cells was promoted and repressed after transfection of sense and antisense miR-210, respectively. A reporter assay demonstrated that the activin A receptor type 1B (AcvR1b) gene was a target for miR-210. Furthermore, inhibition of transforming growth factor-beta (TGF-beta)/activin signaling in ST2 cells with SB431542 promoted osteoblastic differentiation. We conclude that miR-210 acts as a positive regulator of osteoblastic differentiation by inhibiting the TGF-beta/activin signaling pathway through inhibition of AcvR1b.
|
| Volume |
583(13)
|
| Pages |
2263-8
|
| Published |
2009-7-7
|
| DOI |
10.1016/j.febslet.2009.06.006
|
| PII |
S0014-5793(09)00449-9
|
| PMID |
19520079
|
| MeSH |
Activin Receptors, Type I / antagonists & inhibitors*
Activin Receptors, Type I / metabolism
Animals
Bone Morphogenetic Protein 4 / metabolism
Cell Differentiation*
Cells, Cultured
Mice
MicroRNAs / metabolism*
Osteoblasts / cytology*
Osteoblasts / metabolism
Signal Transduction
Transfection
Transforming Growth Factor beta / metabolism
|
| IF |
3.057
|
| Times Cited |
169
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
ST2(RCB0224)
NRG(RCB1921) |
