Reference - Detail
| RRC ID | 37756 |
|---|---|
| Author | Mizuno Y, Tokuzawa Y, Ninomiya Y, Yagi K, Yatsuka-Kanesaki Y, Suda T, Fukuda T, Katagiri T, Kondoh Y, Amemiya T, Tashiro H, Okazaki Y. |
| Title | miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b. |
| Journal | FEBS Lett |
| Abstract |
Although microRNAs (miRNAs) are involved in many biological processes, the mechanisms whereby miRNAs regulate osteoblastic differentiation are poorly understood. Here, we found that BMP-4-induced osteoblastic differentiation of bone marrow-derived ST2 stromal cells was promoted and repressed after transfection of sense and antisense miR-210, respectively. A reporter assay demonstrated that the activin A receptor type 1B (AcvR1b) gene was a target for miR-210. Furthermore, inhibition of transforming growth factor-beta (TGF-beta)/activin signaling in ST2 cells with SB431542 promoted osteoblastic differentiation. We conclude that miR-210 acts as a positive regulator of osteoblastic differentiation by inhibiting the TGF-beta/activin signaling pathway through inhibition of AcvR1b. |
| Volume | 583(13) |
| Pages | 2263-8 |
| Published | 2009-7-7 |
| DOI | 10.1016/j.febslet.2009.06.006 |
| PII | S0014-5793(09)00449-9 |
| PMID | 19520079 |
| MeSH | Activin Receptors, Type I / antagonists & inhibitors* Activin Receptors, Type I / metabolism Animals Bone Morphogenetic Protein 4 / metabolism Cell Differentiation* Cells, Cultured Mice MicroRNAs / metabolism* Osteoblasts / cytology* Osteoblasts / metabolism Signal Transduction Transfection Transforming Growth Factor beta / metabolism |
| IF | 3.057 |
| Times Cited | 169 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | ST2(RCB0224) NRG(RCB1921) |