論文 - 詳細
| RRC ID | 37759 |
|---|---|
| 著者 | Ando C, Takahashi N, Hirai S, Nishimura K, Lin S, Uemura T, Goto T, Yu R, Nakagami J, Murakami S, Kawada T. |
| タイトル | Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation. |
| ジャーナル | FEBS Lett |
| Abstract |
Interaction between adipocytes and macrophages contributes to the development of insulin resistance in obese adipose tissues. In this study, we examined whether luteolin, food-derived flavonoid, could suppress the production of inflammatory mediators of the interaction between adipocytes and macrophages. Experiments using a coculture system of adipocytes and macrophages showed that luteolin suppressed the production of inflammatory mediators. In addition, activated macrophages were targets for the suppressive effect of luteolin. Luteolin inhibited the phosphorylation of JNK and suppressed the production of inflammatory mediators in the activated macrophages. The findings indicate that luteolin can inhibit the interaction between adipocytes and macrophages to suppress the production of inflammatory mediators, suggesting that luteolin is a valuable food-derived compound for the treatment of metabolic syndrome. |
| 巻・号 | 583(22) |
| ページ | 3649-54 |
| 公開日 | 2009-11-19 |
| DOI | 10.1016/j.febslet.2009.10.045 |
| PII | S0014-5793(09)00833-3 |
| PMID | 19854181 |
| MeSH | 3T3-L1 Cells Adipocytes / cytology Adipocytes / drug effects* Adipocytes / metabolism Animals Blotting, Western Cell Communication / drug effects Cell Line Coculture Techniques Culture Media, Conditioned / pharmacology Dose-Response Relationship, Drug Enzyme Activation / drug effects Enzyme-Linked Immunosorbent Assay Flavonoids / pharmacology Food I-kappa B Proteins / metabolism Inflammation Mediators / metabolism JNK Mitogen-Activated Protein Kinases / metabolism* Luteolin / pharmacology* Macrophages / cytology Macrophages / drug effects* Macrophages / metabolism Mice Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha / genetics Tumor Necrosis Factor-alpha / metabolism |
| IF | 3.057 |
| 引用数 | 51 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |