| RRC ID |
37773
|
| 著者 |
Shirai T, Tsuchiya H, Shimizu T, Ohtani K, Zen Y, Tomita K.
|
| タイトル |
Prevention of pin tract infection with titanium-copper alloys.
|
| ジャーナル |
J Biomed Mater Res B Appl Biomater
|
| Abstract |
The most frequent complication in external fixation is pin tract infection. To reduce the incidence of implant-associated infection, many published reports have looked at preventing bacterial adhesion by treating the pin surface. This study aimed to evaluate the antibacterial activity of a Titanium-Copper (Ti-Cu) alloy on implant infection, and to determine the potential use of the Ti-Cu alloy as a biomaterial. Two forms of Ti-Cu alloys were synthesized: one with 1% Cu and the other with 5% Cu. For analyzing infectious behavior, the implants were exposed to Staphylococcus aureus and Escherichia coli. The reaction of pathogens to the Ti-Cu alloys was compared with their reaction to stainless steel and pure titanium as controls. Both Ti-Cu alloys evidently inhibited colonization by both bacteria. Conversely, cytocompatibility studies were performed using fibroblasts and colony formation on the metals was assessed by counting the number of colonies. Ti-1% Cu alloy showed no difference in the number of colonies compared with the control. External fixator pins made of Ti-Cu alloys were evaluated in a rabbit model. The tissue-implant interactions were analyzed for the presence of infection, inflammatory changes and osteoid-formation. Ti-1% Cu alloy significantly inhibited inflammation and infection, and had excellent osteoid-formation. Copper blood levels were measured before surgery and at 14 days postoperatively. Preoperative and postoperative blood copper values were not statistically different. Overall, it was concluded that Ti-Cu alloys have antimicrobial activity and substantially reduce the incidence of pin tract infection. Ti-1% Cu alloy shows particular promise as a biomaterial.
|
| 巻・号 |
91(1)
|
| ページ |
373-80
|
| 公開日 |
2009-10-1
|
| DOI |
10.1002/jbm.b.31412
|
| PMID |
19507137
|
| MeSH |
Alloys / chemistry*
Animals
Anti-Infective Agents / chemistry
Bacterial Infections / prevention & control*
Biocompatible Materials / chemistry
Copper / chemistry*
Cricetinae
Cricetulus
External Fixators* / adverse effects
External Fixators* / microbiology
Female
Fibroblasts / cytology
Fibroblasts / physiology
Materials Testing
Rabbits
Stainless Steel / chemistry
Titanium / chemistry*
|
| IF |
2.831
|
| 引用数 |
112
|
|
WOS 分野
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| リソース情報 |
| ヒト・動物細胞 |
V79(RCB0008) |
