論文 - 詳細
| RRC ID | 37799 |
|---|---|
| 著者 | Shiba T, Maruyama T, Kurohane K, Iwasaki Y, Watanabe T, Imai Y. |
| タイトル | TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity. |
| ジャーナル | J Neuroimmunol |
| Abstract |
We have revealed that local stimulation of sensory neurons is involved in the adjuvant effect of dibutyl phthalate (DBP) in a fluorescein isothiocyanate-induced mouse contact hypersensitivity model. Transient receptor potential (TRP) A1 and TRPV1 seemed to be candidate DBP targets. Here we directly demonstrated that DBP activates a subset of neurons in mouse dorsal root ganglia responsive to TRPA1 and TRPV1 agonists. TRPA1 and TRPV1 activation was further demonstrated using cultured cells expressing TRP channels. Among structurally different phthalate esters, there is a positive relationship between the activation of TRPA1- or TRPV1-expressing cells and the adjuvant effect. |
| 巻・号 | 207(1-2) |
| ページ | 66-74 |
| 公開日 | 2009-2-15 |
| DOI | 10.1016/j.jneuroim.2008.12.001 |
| PII | S0165-5728(08)00491-8 |
| PMID | 19135264 |
| MeSH | Animals CHO Cells Calcium / metabolism Capsaicin / pharmacology Cricetinae Cricetulus Dermatitis, Contact / etiology Dermatitis, Contact / immunology* Dermatitis, Contact / metabolism* Dermatitis, Contact / pathology Dibutyl Phthalate / pharmacology Disease Models, Animal Dose-Response Relationship, Drug Edema / etiology Edema / pathology Female Fluorescein-5-isothiocyanate / adverse effects Fluorescent Dyes / adverse effects Ganglia, Spinal / cytology Gene Expression / drug effects Gene Expression / physiology Isothiocyanates / pharmacology Mice Mice, Inbred BALB C Plasticizers / pharmacology Rats Sensory Receptor Cells / drug effects* Sensory Receptor Cells / metabolism TRPA1 Cation Channel TRPV Cation Channels / genetics TRPV Cation Channels / metabolism* Transfection / methods Transient Receptor Potential Channels / genetics Transient Receptor Potential Channels / metabolism* |
| IF | 3.125 |
| 引用数 | 23 |
| WOS 分野 | IMMUNOLOGY NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | |