| RRC ID |
37799
|
| 著者 |
Shiba T, Maruyama T, Kurohane K, Iwasaki Y, Watanabe T, Imai Y.
|
| タイトル |
TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity.
|
| ジャーナル |
J Neuroimmunol
|
| Abstract |
We have revealed that local stimulation of sensory neurons is involved in the adjuvant effect of dibutyl phthalate (DBP) in a fluorescein isothiocyanate-induced mouse contact hypersensitivity model. Transient receptor potential (TRP) A1 and TRPV1 seemed to be candidate DBP targets. Here we directly demonstrated that DBP activates a subset of neurons in mouse dorsal root ganglia responsive to TRPA1 and TRPV1 agonists. TRPA1 and TRPV1 activation was further demonstrated using cultured cells expressing TRP channels. Among structurally different phthalate esters, there is a positive relationship between the activation of TRPA1- or TRPV1-expressing cells and the adjuvant effect.
|
| 巻・号 |
207(1-2)
|
| ページ |
66-74
|
| 公開日 |
2009-2-15
|
| DOI |
10.1016/j.jneuroim.2008.12.001
|
| PII |
S0165-5728(08)00491-8
|
| PMID |
19135264
|
| MeSH |
Animals
CHO Cells
Calcium / metabolism
Capsaicin / pharmacology
Cricetinae
Cricetulus
Dermatitis, Contact / etiology
Dermatitis, Contact / immunology*
Dermatitis, Contact / metabolism*
Dermatitis, Contact / pathology
Dibutyl Phthalate / pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Edema / etiology
Edema / pathology
Female
Fluorescein-5-isothiocyanate / adverse effects
Fluorescent Dyes / adverse effects
Ganglia, Spinal / cytology
Gene Expression / drug effects
Gene Expression / physiology
Isothiocyanates / pharmacology
Mice
Mice, Inbred BALB C
Plasticizers / pharmacology
Rats
Sensory Receptor Cells / drug effects*
Sensory Receptor Cells / metabolism
TRPA1 Cation Channel
TRPV Cation Channels / genetics
TRPV Cation Channels / metabolism*
Transfection / methods
Transient Receptor Potential Channels / genetics
Transient Receptor Potential Channels / metabolism*
|
| IF |
3.125
|
| 引用数 |
23
|
|
WOS 分野
|
IMMUNOLOGY
NEUROSCIENCES
|
| リソース情報 |
| ヒト・動物細胞 |
|
