論文 - 詳細
| RRC ID | 37808 |
|---|---|
| 著者 | Satoh C, Tamura H, Yamashita T, Tsuji T, Dan K, Ogata K. |
| タイトル | Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromes. |
| ジャーナル | Leuk Res |
| Abstract |
Clinical data suggest that CD7+ myeloblasts are linked with poor prognosis in myeloid malignancies including myelodysplastic syndromes (MDS). To explore the biology behind this, we compared cell characteristics between CD34+CD7+ and CD34+CD7- myeloblasts from an MDS cell line and fresh samples from MDS patients. Compared with CD34+CD7- myeloblasts, CD34+CD7+ myeloblasts showed greater proliferative capacity, more active cell cycling, and less apoptosis. In analyses of a cell line, CD34+CD7+ myeloblasts produced CD34+CD7- myeloblasts and showed lower expressions of interleukin-8 and chemokine (C-C motif) ligand 2 genes, suggesting immaturity of these cells. These findings might underlie the clinical aggressiveness in CD7+ MDS. |
| 巻・号 | 33(2) |
| ページ | 326-31 |
| 公開日 | 2009-2-1 |
| DOI | 10.1016/j.leukres.2008.07.006 |
| PII | S0145-2126(08)00335-4 |
| PMID | 18718658 |
| MeSH | Antigens, CD7* Apoptosis Cell Cycle Cell Proliferation Chemokines, C / analysis Granulocyte Precursor Cells / metabolism* Granulocyte Precursor Cells / pathology Humans Immunophenotyping Interleukin-8 / analysis Myelodysplastic Syndromes / pathology* Tumor Cells, Cultured |
| IF | 2.214 |
| 引用数 | 13 |
| WOS 分野 | HEMATOLOGY ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | F-36P(RCB0775) |