論文 - 詳細
| RRC ID | 37861 |
|---|---|
| 著者 | Akamine K, Koyama T, Yazawa K. |
| タイトル | Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia. |
| 巻・号 | 73(9) |
| ページ | 1911-4 |
| 公開日 | 2009-9-1 |
| DOI | 10.1271/bbb.80770 |
| PII | JST.JSTAGE/bbb/80770 |
| PMID | 19734683 |
| MeSH | Animals Cell Line, Tumor Dose-Response Relationship, Drug Humans Male Mice Musa / chemistry* Plant Extracts / administration & dosage Plant Extracts / pharmacology* Prostate / drug effects Prostate / growth & development Prostatic Hyperplasia / prevention & control* Seminal Vesicles / drug effects Seminal Vesicles / growth & development Testosterone / adverse effects* |
| IF | 1.516 |
| 引用数 | 8 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |