論文 - 詳細
| RRC ID | 37869 |
|---|---|
| 著者 | Takahashi J, Takagi Y, Saiki H. |
| タイトル | Transplantation of embryonic stem cell-derived dopaminergic neurons in MPTP-treated monkeys. |
| ジャーナル | Methods Mol Biol |
| Abstract |
One of the target diseases of cell-replacement therapy is Parkinson's disease. Clinical experiences with fetal dopaminergic cell graft have shown that the therapy is effective, but limited and accompanied by side effects, such as dyskinesia. So, the therapy needs to be further improved and sophisticated. Embryonic stem (ES) cells are expected to be another donor cell for the treatment, because of its proliferative and differentiation capacities. For clinical application, experiments using non-human primates are important, because size, anatomy, and biological characteristics of the brain are different between rodents and primates. Here, we would like to discuss induction of dopaminergic neurons from monkey ES cells and cell transplantation into the brain of monkey Parkinson's disease model. |
| 巻・号 | 482 |
| ページ | 199-212 |
| 公開日 | 2009-1-1 |
| DOI | 10.1007/978-1-59745-060-7_13 |
| PMID | 19089358 |
| MeSH | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Behavior, Animal Cell Survival Disease Models, Animal Dopamine / metabolism* Embryonic Stem Cells / cytology* Fluorescent Antibody Technique Haplorhini / metabolism* Magnetic Resonance Imaging Male Mice Neostriatum / cytology Neurons / cytology* Neurons / transplantation* Parkinson Disease / therapy Positron-Emission Tomography Spheroids, Cellular / cytology Stem Cell Transplantation / methods* Tissue Culture Techniques |
| リソース情報 | |
| ヒト・動物細胞 | STO(RCB0536) MC3T3-G2/PA6(RCB1127) |