Reference - Detail
RRC ID | 37872 |
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Author | Hazawa M, Wada K, Takahashi K, Mori T, Kawahara N, Kashiwakura I. |
Title | Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth. |
Journal | Invest New Drugs |
Abstract |
Little information has so far been reported regarding the antiproliferative properties of Aconitum alkaloids against human tumor cells despite of their intense toxicities. In the present study, the antitumor properties and radiation sensitizing effects were investigated by various types of novel derivatives prepared from Aconitum alkaloids. The antitumor properties were investigated against human tumor cell lines, A172, A549, HeLa and Raji, respectively, by a cell growth, a clonogenic assay, cell cycle distribution, cell cycle related molecules and gammaH2AX expression. The novel compounds derived from C(20)-diterupenoid alkaloids showed a significantly suppressive effect in all cell lines. In contrast, natural C(19)-norditerpenoid alkaloids and their derivatives showed either no effect or only a slight effect. One of the compounds also showed radiosensitizing properties on A549 cells. These effects are not related to either the cell cycle distribution, the enhancement of apoptosis or the gammaH2AX expression. Novel derivatives prepared from Aconitum alkaloids, not but natural alkaloids, clearly showed anti-proliferative activity in human tumor cell lines. |
Volume | 27(2) |
Pages | 111-9 |
Published | 2009-4-1 |
DOI | 10.1007/s10637-008-9141-4 |
PMID | 18551247 |
MeSH | Aconitum / chemistry* Alkaloids / isolation & purification Alkaloids / therapeutic use* Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / therapeutic use* Cell Cycle / drug effects Cell Cycle / radiation effects Cell Line, Tumor Cell Proliferation / drug effects Cell Proliferation / radiation effects Combined Modality Therapy Drug Screening Assays, Antitumor Histones / metabolism Humans Neoplasms / drug therapy* Plant Preparations / analogs & derivatives* Plant Preparations / chemistry Plant Preparations / therapeutic use* Plant Roots Radiation-Sensitizing Agents / chemistry Radiation-Sensitizing Agents / therapeutic use* |
IF | 3.525 |
Times Cited | 31 |
WOS Category | PHARMACOLOGY & PHARMACY ONCOLOGY |
Resource | |
Human and Animal Cells | A549(RCB0098) HeLa(RCB0007) RAJI(RCB1647) |