論文 - 詳細
| RRC ID | 3803 |
|---|---|
| 著者 | Kimura M. |
| タイトル | IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. |
| ジャーナル | FEBS Lett |
| Abstract |
Jun-dimerization protein 2 (JDP2) is a member of the activating protein-1 (AP-1) family of transcription factors. JDP2 dimerizes with other AP-1 proteins such as activating transcription factor-2 (ATF2) and Jun to repress transcription from promoters that contain a cyclic AMP-responsive element (CRE). Interferon regulatory factor-2-binding protein-1 (IRF2-BP1), which is reported to be a transcriptional corepressor of IRF2, was isolated as a JDP2-binding protein using an epitope-tagging method. As anticipated from the presence of a RING-finger domain, IRF2-BP1 enhanced the polyubiquitination of JDP2. Moreover, IRF2-BP1 repressed ATF2-mediated transcriptional activation from a CRE-containing promoter. |
| 巻・号 | 582(19) |
| ページ | 2833-7 |
| 公開日 | 2008-8-20 |
| DOI | 10.1016/j.febslet.2008.07.033 |
| PII | S0014-5793(08)00624-8 |
| PMID | 18671972 |
| MeSH | Activating Transcription Factor 2 / antagonists & inhibitors Activating Transcription Factor 2 / metabolism* Amino Acid Sequence Carrier Proteins / metabolism* Genes, Reporter HeLa Cells Humans Luciferases / genetics Molecular Sequence Data Promoter Regions, Genetic Repressor Proteins / metabolism* Transcription, Genetic Transcriptional Activation* Ubiquitin-Protein Ligases / metabolism* Ubiquitination* |
| IF | 3.057 |
| 引用数 | 14 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 遺伝子材料 | phRL-3CRE-TK (RDB03459) |
| ヒト・動物細胞 | HeLa.S3(RCB0191) Hep G2 |