論文 - 詳細
| RRC ID | 38130 |
|---|---|
| 著者 | Ohgami N, Yamanoshita O, Thang ND, Yajima I, Nakano C, Wenting W, Ohnuma S, Kato M. |
| タイトル | Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood. |
| ジャーナル | Environ Pollut |
| Abstract |
We showed that 2.1% of 233 pieces of lumber debris after the Great East Japan Earthquake was chromated copper arsenate (CCA)-treated wood. Since hexavalent chromium (Cr), copper (Cu) and pentavalent arsenic (As) in the debris may be diffused in the air via incineration, we exposed human lung normal (BEAS-2B) and carcinoma (A549) cells to Cr, Cu and As at the molar ratio in a representative CCA-treated wood. Co-exposure to 0.10 μM Cr and 0.06 μM As, which solely had no effect on colony formation, synergistically promoted colony formation in BEAS-2B cells, but not A549 cells, with activation of the PI3K/AKT pathway. Sole exposure and co-exposure to Cu showed limited effects. Since previous reports showed Cr and As concentrations to which human lungs might be exposed, our results suggest the importance to avoid diffusion of Cr and As in the air via incineration of debris including CCA-treated wood after the disaster. |
| 巻・号 | 206 |
| ページ | 456-60 |
| 公開日 | 2015-11-1 |
| DOI | 10.1016/j.envpol.2015.07.041 |
| PII | S0269-7491(15)00374-7 |
| PMID | 26275730 |
| MeSH | Arsenates / analysis* Arsenates / toxicity Arsenic / analysis* Arsenic / toxicity Carcinogens / analysis* Carcinogens / toxicity Cell Line, Tumor Cell Survival / drug effects Chromium / analysis* Chromium / toxicity Copper / analysis* Copper / toxicity Humans Incineration Japan Phosphatidylinositol 3-Kinases / metabolism Wood / chemistry* |
| IF | 6.793 |
| 引用数 | 20 |
| WOS 分野 | ENVIRONMENTAL SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549 |