論文 - 詳細
| RRC ID | 38155 |
|---|---|
| 著者 | Watson SL, Daniels JT, Geerling G, Dart JK. |
| タイトル | Clinical trials of therapeutic ocular surface medium for moderate to severe dry eye. |
| ジャーナル | Cornea |
| Abstract |
PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for moderate to severe dry eye. METHODS:Forty-six patients with symptoms of moderate to severe dry eye despite maximal standard therapy were enrolled in a prospective pilot study of TOSM over 1 month (n = 10) and a randomized, double-masked, controlled trial of TOSM versus saline (placebo) over 2 months (n = 36). The primary outcome measure was conjunctival rose bengal staining. RESULTS:An improvement in conjunctival rose bengal staining by ≥3 points occurred in 7 of 10 patients receiving TOSM in the pilot study (P = 0.017) and in 8 of 18 patients (44%) in the randomized trial (P = 0.982). In the pilot study, subjective dry eye symptoms significantly improved (P = 0.005). TOSM significantly improved the blepharitis score (P = 0.002) and conjunctival impression cytology (P = 0.028) in the randomized controlled trial. There were no serious or irreversible side effects with TOSM. CONCLUSIONS:TOSM is a physiological tear replacement for dry eye that, unlike autologous serum, can be easily manufactured, could be widely available, and may also be beneficial for blepharitis. |
| 巻・号 | 29(11) |
| ページ | 1241-6 |
| 公開日 | 2010-11-1 |
| DOI | 10.1097/ICO.0b013e3181d82f5e |
| PMID | 20697273 |
| MeSH | Adult Aged Blepharitis / drug therapy Blepharitis / pathology Cell Survival / drug effects Conjunctiva / pathology Double-Blind Method Dry Eye Syndromes / drug therapy* Dry Eye Syndromes / pathology Dry Eye Syndromes / physiopathology Female Fluorescent Dyes Humans Male Middle Aged Ophthalmic Solutions / therapeutic use* Pilot Projects Prospective Studies Rose Bengal Severity of Illness Index Staining and Labeling Young Adult |
| IF | 2.215 |
| 引用数 | 12 |
| WOS 分野 | OPHTHALMOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | HCE-T(RCB2280) |