論文 - 詳細
| RRC ID | 38197 |
|---|---|
| 著者 | Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T. |
| タイトル | Expanding role of the jumonji C domain as an RNA hydroxylase. |
| ジャーナル | J Biol Chem |
| Abstract |
JmjC (Jumonji C) domain-containing proteins are known to be an extensive family of Fe(II)/2-oxoglutarate-dependent oxygenases involved in epigenetic regulation of gene expression by catalyzing oxidative demethylation of methylated histones. We report here that a human JmjC protein named Tyw5p (TYW5) unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxywybutosine, in tRNA(Phe) by catalyzing hydroxylation. The finding provides an insight into the expanding role of JmjC protein as an RNA hydroxylase. |
| 巻・号 | 285(45) |
| ページ | 34503-7 |
| 公開日 | 2010-11-5 |
| DOI | 10.1074/jbc.M110.156398 |
| PII | S0021-9258(20)46991-1 |
| PMID | 20739293 |
| PMC | PMC2966065 |
| MeSH | Guanine / analogs & derivatives* Guanine / metabolism HeLa Cells Humans Hydroxylation Mixed Function Oxygenases / genetics Mixed Function Oxygenases / metabolism* Protein Structure, Tertiary RNA, Transfer, Phe / genetics RNA, Transfer, Phe / metabolism* Saccharomyces cerevisiae / genetics |
| IF | 4.238 |
| 引用数 | 46 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Ehrlich(RCB0142) |