| RRC ID |
38294
|
| Author |
Arung ET, Shimizu K, Tanaka H, Kondo R.
|
| Title |
3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus.
|
| Journal |
Fitoterapia
|
| Abstract |
In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC(50) of mushroom tyrosinase inhibitory activity of 1 was 76.3 microM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC(50) of 1 was 56.7 microM with less cytotoxicity.
|
| Volume |
81(6)
|
| Pages |
640-3
|
| Published |
2010-9-1
|
| DOI |
10.1016/j.fitote.2010.03.011
|
| PII |
S0367-326X(10)00070-5
|
| PMID |
20230878
|
| MeSH |
Animals
Artocarpus / chemistry*
Cell Line, Tumor
Drug Evaluation, Preclinical
Flavones / chemistry
Flavones / isolation & purification
Flavones / pharmacology*
Luteolin / chemistry
Luteolin / isolation & purification*
Melanins / antagonists & inhibitors*
Melanins / biosynthesis
Mice
Monophenol Monooxygenase / antagonists & inhibitors*
Plants, Medicinal / chemistry
Wood / chemistry
|
| IF |
2.527
|
| Times Cited |
21
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| Resource |
| Human and Animal Cells |
B16 |
