論文 - 詳細
| RRC ID | 38295 |
|---|---|
| 著者 | Arung ET, Yoshikawa K, Shimizu K, Kondo R. |
| タイトル | Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cells: cytotoxicity and structural criteria. |
| ジャーナル | Fitoterapia |
| Abstract |
As a result of cytotoxicity-guided fractionation, nine flavonoids, artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5), albanin A (6), cudraflavone B (7), brosimone I (8) and artocarpanone (9) were identified from the methanol extract of the wood of Artocarpus heterophyllus, known commonly as Nangka in Indonesia. A structure-activity investigation of the effect of these isolated compounds (1-9) and structurally related compounds on B16 melanoma cells indicated that isoprenoid moiety substitutions in flavonoids enhance their cytotoxicity, and that the position of attachment and the number of isoprenoid-substituent moieties per molecule influence flavonoid cytotoxicity. |
| 巻・号 | 81(2) |
| ページ | 120-3 |
| 公開日 | 2010-3-1 |
| DOI | 10.1016/j.fitote.2009.08.001 |
| PII | S0367-326X(09)00174-9 |
| PMID | 19686821 |
| MeSH | Animals Artocarpus / chemistry* Cell Line, Tumor Flavonoids / chemistry Flavonoids / isolation & purification Flavonoids / pharmacology* Flavonoids / therapeutic use Melanoma, Experimental / drug therapy* Mice Molecular Structure Phytotherapy Plant Extracts / chemistry Plant Extracts / pharmacology* Plant Stems Skin Neoplasms / drug therapy* Structure-Activity Relationship Terpenes Wood |
| IF | 2.527 |
| 引用数 | 44 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | |