論文 - 詳細
| RRC ID | 38301 |
|---|---|
| 著者 | Yamamoto K, Sakaguchi M, Medina RJ, Niida A, Sakaguchi Y, Miyazaki M, Kataoka K, Huh NH. |
| タイトル | Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Several growth factors and transcription factors have been reported to play important roles in brown adipocyte differentiation and modulation of thermogenic gene expression, especially the expression of UCP1. In this study, we focused on KLF11 and KLF15, which were expressed highly in brown adipose tissue. Our data demonstrated that KLF11 and KLF15 interacted directly with the UCP1 promoter using GC-box and GT-boxes, respectively. Co-transfection of KLF11 and KLF15 in the mesenchymal stem cell line muBM3.1 during brown adipocyte differentiation enhanced the expression level of UCP1. KLF11, but not KLF15, was essential for UCP1 expression during brown adipocyte differentiation of muBM3.1. |
| 巻・号 | 400(1) |
| ページ | 175-80 |
| 公開日 | 2010-9-10 |
| DOI | 10.1016/j.bbrc.2010.08.039 |
| PII | S0006-291X(10)01525-1 |
| PMID | 20709022 |
| MeSH | Adipocytes, Brown / metabolism* Adipogenesis / genetics* Apoptosis Regulatory Proteins Binding Sites Cell Cycle Proteins / metabolism* Cell Line Gene Expression Regulation* Humans Ion Channels / genetics* Kruppel-Like Transcription Factors / metabolism* Mesenchymal Stem Cells Mitochondrial Proteins / genetics* Nuclear Proteins / metabolism* Promoter Regions, Genetic Repressor Proteins / metabolism* Transcription, Genetic Uncoupling Protein 1 |
| IF | 2.985 |
| 引用数 | 25 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293(RCB1637) |