RRC ID 38306
著者 Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.
タイトル Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.
ジャーナル Biochem Biophys Res Commun
Abstract Streptococcus sanguinis is a predominant bacterium in the human oral cavity and occasionally causes infective endocarditis. We identified a unique cell surface polymeric structure named pili in this species and investigated its functions in regard to its potential virulence. Pili of S. sanguinis strain SK36 were shown to be composed of three distinctive pilus proteins (PilA, PilB, and PilC), and a pili-deficient mutant demonstrated reduced bacterial adherence to HeLa and human oral epithelial cells. PilC showed a binding ability to fibronectin, suggesting that pili are involved in colonization by this species. In addition, ATCC10556, a standard S. sanguinis strain, was unable to produce pili due to defective pilus genes, which indicates a diversity of pilus expression among various S. sanguinis strains.
巻・号 391(2)
ページ 1192-6
公開日 2010-1-8
DOI 10.1016/j.bbrc.2009.12.029
PII S0006-291X(09)02402-4
PMID 20004645
MeSH Bacterial Adhesion* Bacterial Proteins / genetics Bacterial Proteins / metabolism* Fibronectins / blood Fibronectins / metabolism* Fimbriae, Bacterial / genetics Fimbriae, Bacterial / metabolism* Humans Mouth / microbiology* Streptococcus sanguis / genetics Streptococcus sanguis / metabolism Streptococcus sanguis / pathogenicity*
IF 2.985
引用数 27
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 HSC-2(RCB1945) heLa(RCB0007)