RRC ID 38308
著者 Unno A, Kitoh K, Takashima Y.
タイトル Up-regulation of hyaluronan receptors in Toxoplasma gondii-infected monocytic cells.
ジャーナル Biochem Biophys Res Commun
Abstract The apicomplexan, obligate intracellular parasite Toxoplasma gondii orally infects humans and animals. The parasites cross the intestinal epithelium, invade leukocytes in the general circulation and then disseminate into the peripheral organs. The mechanism of extravasation of the infected leukocytes, however, remains poorly understood. It is known that adhesion of leukocytes to extracellular matrix (ECM) is an important factor in extravasation, and CD44 and ICAM-1 on the leukocyte surface are known receptors for hyaluronan (HA), an ECM component. In this study, we demonstrated up-regulation of CD44 and ICAM-1 expression on the surface of T. gondii-infected human monocytic THP-1 cells and fresh isolated human monocyte. T. gondii-infected THP-1 cells adhered more efficiently to immobilized HA than did non-infected cells. T. gondii-infected monocytes in the general circulation might preferentially adhere to the ECM and migrate out from blood vessels, so transporting parasites into the peripheral organs.
巻・号 391(1)
ページ 477-80
公開日 2010-1-1
DOI 10.1016/j.bbrc.2009.11.083
PII S0006-291X(09)02258-X
PMID 19914206
MeSH Cell Adhesion Humans Hyaluronan Receptors / metabolism* Intercellular Adhesion Molecule-1 / metabolism* Monocytes / immunology* Monocytes / parasitology Toxoplasma* Toxoplasmosis / immunology* Up-Regulation
IF 2.985
引用数 9
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 HL60(RCB0041) THP-1(RCB1189)