| RRC ID |
38327
|
| Author |
Shintani S, Hamakawa H, Nakashiro K, Shirota T, Hatori M, Tanaka M, Kuroshita Y, Kurokawa Y.
|
| Title |
Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral squamous cell carcinoma.
|
| Journal |
Int J Oral Maxillofac Surg
|
| Abstract |
Radiotherapy is commonly used to treat oral squamous cell carcinoma (OSCC), but its therapeutic effects are unpredictable. To determine which genes correlate with radiation resistance in oral cancer, the authors evaluated radiation sensitivity using a standard colony formation assay with a gene microarray system for seven OSCC cell lines. They found significant associations between dozens of gene-expression levels and radiation resistance of OSCC cell lines. Following analysis of the different radiosensitive cancer cell lines, the friend leukaemia insertion (Fli)-1 gene was selected as a prediction marker gene for OSCC radiotherapy resistance. Fli-1 expression was associated with radiation resistance in OSCC patients. These data help to predict the effects radiation therapy has on OSCC, in turn contributing to the development of alternative radiation therapies.
|
| Volume |
39(11)
|
| Pages |
1115-9
|
| Published |
2010-11-1
|
| DOI |
10.1016/j.ijom.2010.02.027
|
| PII |
S0901-5027(10)00304-8
|
| PMID |
20709497
|
| MeSH |
Biomarkers, Tumor / metabolism*
Carcinoma, Squamous Cell / genetics
Carcinoma, Squamous Cell / metabolism*
Carcinoma, Squamous Cell / radiotherapy
Cell Line, Tumor
Gene Expression Profiling
Humans
Microarray Analysis
Mouth Neoplasms / genetics
Mouth Neoplasms / metabolism*
Mouth Neoplasms / radiotherapy
Predictive Value of Tests
Proto-Oncogene Protein c-fli-1 / metabolism*
|
| IF |
2.068
|
| Times Cited |
8
|
|
WOS Category
|
SURGERY
DENTISTRY, ORAL SURGERY & MEDICINE
|
| Resource |
| Human and Animal Cells |
|
