RRC ID 38329
Author Nagai N, Kawao N, Okada K, Okumoto K, Teramura T, Ueshima S, Umemura K, Matsuo O.
Title Systemic transplantation of embryonic stem cells accelerates brain lesion decrease and angiogenesis.
Journal Neuroreport
Abstract As stem cells can regenerate damaged tissue, their therapeutic potential on brain damage has been investigated. In this study, the effects of embryonic stem cell transplantation on brain damage were investigated by using a photochemically induced thrombotic brain damage model. Mice with systemic transplantation of embryonic stem cells expressing enhanced green fluorescence protein on day 1 showed a smaller brain lesion size on day 8 than the control mice. The smaller lesion was accompanied by the increase in the number of microvessels at the border of the damaged area. Inside and around the damaged lesion, no EGFP-positive cells were observed. These findings suggested that embryonic stem cell transplantation reduced the brain lesion through the acceleration of angiogenesis by endogenous endothelial cells.
Volume 21(8)
Pages 575-9
Published 2010-6-2
DOI 10.1097/WNR.0b013e32833a7d2c
PMID 20431496
MeSH Animals Brain Edema / etiology Brain Edema / physiopathology Brain Edema / surgery Brain Infarction / pathology Brain Infarction / physiopathology Brain Infarction / surgery* Capillaries / cytology Capillaries / physiology Cell Culture Techniques Cell Line Disease Models, Animal Embryonic Stem Cells / cytology Embryonic Stem Cells / physiology Embryonic Stem Cells / transplantation* Fluorescent Dyes / radiation effects Fluorescent Dyes / toxicity Intracranial Thrombosis / pathology Intracranial Thrombosis / physiopathology Intracranial Thrombosis / surgery* Male Mice Mice, Inbred C57BL Microcirculation / physiology Neoplasms / etiology Neoplasms / pathology Neoplasms / physiopathology Neovascularization, Physiologic / physiology* Nerve Regeneration / physiology* Photic Stimulation / adverse effects Postoperative Complications / etiology Postoperative Complications / pathology Postoperative Complications / physiopathology Risk Assessment Rose Bengal / radiation effects Rose Bengal / toxicity Stem Cell Transplantation / adverse effects Stem Cell Transplantation / methods* Transplantation, Homologous / adverse effects Transplantation, Homologous / methods
IF 1.394
Times Cited 13
Human and Animal Cells