論文 - 詳細
RRC ID | 38342 |
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著者 | Akazawa H, Fujita Y, Banno N, Watanabe K, Kimura Y, Manosroi A, Manosroi J, Akihisa T. |
タイトル | Three new cyclic diarylheptanoids and other phenolic compounds from the bark of Myrica rubra and their melanogenesis inhibitory and radical scavenging activities. |
ジャーナル | J Oleo Sci |
Abstract |
Ten cyclic diarylheptanoids (1-10), including three new compounds: myricanone 5-O-alpha-L-arabinofuranosyl-(1-->6)-beta-D-glucopyranoside (7), myricanone 17-O-beta-D-(6'-O-galloyl)-glucopyranoside (8), and 16-methoxy acerogenin B 9-O-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside (10), along with two flavonoids (11, 12), were isolated from the extracts of Myrica rubra (Myricaceae) bark. The structures of new compounds were determined on the basis of spectroscopic methods. On evaluation of compounds 1-12 against the melanogenesis in the B16 melanoma cells, six compounds, 3, 5, 7, 8, 10, and 12, exhibited inhibitory effects with 30-56% reduction of melanin content at 25 microg/mL with no or very weak toxicity to the cells (82-103% of cell viability at 25 microg/mL). In addition, upon evaluation of compounds 1-12 against the scavenging activities of free radicals [against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical], seven compounds, 1, 3, 5, 6, 8, 11, and 12, showed potent scavenging activity [IC(50) 2-21 microM (0.6-7.3 microg/mL)]. |
巻・号 | 59(4) |
ページ | 213-21 |
公開日 | 2010-1-1 |
DOI | 10.5650/jos.59.213 |
PII | JST.JSTAGE/jos/59.213 |
PMID | 20299768 |
MeSH | Animals Biphenyl Compounds Cattle Depression, Chemical Diarylheptanoids / chemistry Diarylheptanoids / isolation & purification* Diarylheptanoids / pharmacology* Flavonoids / isolation & purification Free Radical Scavengers* Melanins / metabolism* Melanoma, Experimental / metabolism* Melanoma, Experimental / pathology Mice Myricaceae / chemistry* Phenols / chemistry Phenols / isolation & purification* Phenols / pharmacology* Picrates Plant Bark Plant Extracts / chemistry* Tumor Cells, Cultured |
IF | 1.304 |
引用数 | 25 |
WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
リソース情報 | |
ヒト・動物細胞 | B16 murine melanoma |