RRC ID 38343
著者 Manosroi A, Jantrawut P, Akazawa H, Akihisa T, Manosroi J.
タイトル Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae).
ジャーナル Nat Prod Res
Abstract The aqueous extract of galls from Terminalia chebula Retz. (Combretaceae) was fractionated on Diaion and refractionated on octadecyl silica column. Six phenolic compounds were isolated and identified as gallic acid (1), punicalagin (2), isoterchebulin (3), 1,3,6-tri-O-galloyl-β-D-glucopyranose (4), chebulagic acid (5) and chebulinic acid (6). All of the compounds showed stronger 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and melanin inhibitory activities than ascorbic acid, butylated hydroxytoluene, α-tocopherol, arbutin and kojic acid, the reference compounds. Gallic acid (1) exhibited inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophages. However, all isolated compounds exhibited less activity than the reference compounds in mushroom tyrosinase inhibition and human tumour cytotoxicity assays. This study has demonstrated that the phenolic compounds isolated from galls of T. chebula might contribute significantly due to their antioxidant and whitening activities.
巻・号 24(20)
ページ 1915-26
公開日 2010-12-1
DOI 10.1080/14786419.2010.488631
PII 930108356
PMID 21108118
MeSH Analysis of Variance Animals Benzopyrans / chemistry Benzopyrans / isolation & purification Benzopyrans / pharmacology Biphenyl Compounds Cell Line, Tumor Cell Proliferation / drug effects Chemical Fractionation Free Radical Scavengers / isolation & purification Free Radical Scavengers / pharmacology* Gallic Acid / chemistry Gallic Acid / isolation & purification Gallic Acid / pharmacology Glucosides / chemistry Glucosides / isolation & purification Glucosides / pharmacology Humans Hydrolyzable Tannins / chemistry Hydrolyzable Tannins / isolation & purification Hydrolyzable Tannins / pharmacology Melanins / antagonists & inhibitors Mice Molecular Structure Nitric Oxide / antagonists & inhibitors Phenols / chemistry Phenols / isolation & purification Phenols / pharmacology* Picrates Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology* Plant Tumors* Terminalia / chemistry*
IF 2.158
引用数 32
WOS 分野 CHEMISTRY, APPLIED CHEMISTRY, MEDICINAL
リソース情報
ヒト・動物細胞 HL60(RCB0041) SK-BR-3 A549(RCB0098) B16