論文 - 詳細
| RRC ID | 38372 |
|---|---|
| 著者 | Hadisaputri YE, Miyazaki T, Suzuki S, Kubo N, Zuhrotun A, Yokobori T, Abdulah R, Yazawa S, Kuwano H. |
| タイトル | Molecular characterization of antitumor effects of the rhizome extract from Curcuma zedoaria on human esophageal carcinoma cells. |
| ジャーナル | Int J Oncol |
| Abstract |
Curcuma zedoaria has been used as a traditional agent against malignant diseases. To elucidate detailed mechanisms producing such an activity, characterization and determination of molecular mechanisms of its antitumor effects was conducted. Inhibiting activities against cell proliferation, invasion and colony formation, and expression levels of corresponding molecules were investigated using human esophageal cancer TE-8 cells treated with the rhizome extract from C. zedoaria. Antitumor effect of the extract administered orally was also examined in tumor-bearing mice. The extract possessed strong anti-proliferation and invasion activities against TE-8 cells. Further, upregulated PTEN and downregulated phosphorylated Akt, mTOR and STAT3 expressions in the cells were induced shortly after treatment with the extract, followed by attenuation of FGFR1 and MMP-2, activation of caspase-9, caspase-3 and PARP, and suppression of Bcl-2 expressions, which led the cells to apoptotic cell death. Furthermore, tumor formation in mice was significantly suppressed through the oral administration of the extract. Taken together, these results suggest that the C. zedoaria extract could be a promising agent against esophageal cancer. |
| 巻・号 | 47(6) |
| ページ | 2255-63 |
| 公開日 | 2015-12-1 |
| DOI | 10.3892/ijo.2015.3199 |
| PMID | 26498695 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / pharmacology* Apoptosis / drug effects Blotting, Western Carcinoma, Squamous Cell / pathology* Cell Line, Tumor Cell Proliferation / drug effects Curcuma Esophageal Neoplasms / pathology* Esophageal Squamous Cell Carcinoma Female Humans Mice Mice, Inbred BALB C Mice, Nude Plant Extracts / pharmacology* Rhizome Xenograft Model Antitumor Assays |
| IF | 3.899 |
| 引用数 | 5 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | TE-8(RCB2098) |