論文 - 詳細
| RRC ID | 38374 |
|---|---|
| 著者 | Park JW, Kang DG, Hanawa T. |
| タイトル | New bone formation induced by surface strontium-modified ceramic bone graft substitute. |
| ジャーナル | Oral Dis |
| Abstract |
OBJECTIVES:This study assessed the effect of surface strontium ion (Sr) modification on the osteogenic activity of an osteoconductive ceramic bone graft substitute with the hope of using the bone healing effect of Sr for potential application in periodontal and maxillofacial regenerative surgery. MATERIALS AND METHODS:A simple wet chemical treatment was employed to deliver Sr to the surface of particulate porcine bone graft. The osteogenic activity of surface Sr-modified bone substitute was compared in vitro and in vivo with that of unmodified ceramic bone, other clinically available synthetic bone or osteoinductive allograft bone. RESULTS:The resultant bone substitute showed the formation of Sr-containing microstructured surface layer along with the formation of additional nanostructures and displayed sustained Sr release. Sr modification promoted the osteogenic differentiation of bipotential ST2 stem cells. Sr-modified bone substitute increased the amount of newly formed bone at early healing period in calvarial defect of rabbits. CONCLUSIONS:These results suggest that the surface Sr modification by wet chemical treatment is a promising approach to enhance the early bone healing capacity of osteoconductive ceramic bone substitutes. |
| 巻・号 | 22(1) |
| ページ | 53-61 |
| 公開日 | 2016-1-1 |
| DOI | 10.1111/odi.12381 |
| PMID | 26458092 |
| MeSH | Animals Bone Development / drug effects Bone Regeneration / drug effects Bone Substitutes / chemistry* Bone Substitutes / pharmacology* Cell Differentiation Ceramics / chemistry* Ceramics / pharmacology* Maxilla / surgery Maxilla / transplantation Models, Animal Osteoblasts / cytology Osteoblasts / drug effects Osteogenesis / drug effects* Osteogenesis / genetics RNA, Messenger / biosynthesis RNA, Messenger / genetics Rabbits Stromal Cells Strontium / chemistry* Strontium / pharmacology* Surface Properties Swine Transcription Factors |
| IF | 2.613 |
| 引用数 | 3 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |