論文 - 詳細
RRC ID | 38383 |
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著者 | Izumi Y, Yamamoto S, Fujii K, Yokoya A. |
タイトル | Secondary Structure Alterations of Histones H2A and H2B in X-Irradiated Human Cancer Cells: Altered Histones Persist in Cells for at Least 24 Hours. |
ジャーナル | Radiat Res |
Abstract |
We measured and compared the circular dichroism (CD) spectra and secondary structures of histone proteins H2A, H2B and their variants extracted from X-irradiated and unirradiated human HeLa cells. Compared to unirradiated cells, a relative increase in α-helix structure and decrease in other secondary structures was observed in X-irradiated cells. These structural alterations persisted for at least 24 h, which is substantially longer than the 2 h generally known to be required for DNA double-strand break repair. |
巻・号 | 184(5) |
ページ | 554-8 |
公開日 | 2015-11-1 |
DOI | 10.1667/RR14071.1 |
PMID | 26488755 |
MeSH | DNA Repair / radiation effects HeLa Cells Histones / chemistry* Humans Protein Structure, Secondary / radiation effects Time Factors X-Rays / adverse effects |
IF | 2.657 |
引用数 | 6 |
WOS 分野 | BIOLOGY RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BIOPHYSICS |
リソース情報 | |
ヒト・動物細胞 | HeLa/Fucci(RCB2812) |