Reference - Detail
| RRC ID | 38388 |
|---|---|
| Author | Kuroda K, Azuma K, Mori T, Kawamoto K, Murahata Y, Tsuka T, Osaki T, Ito N, Imagawa T, Itoh F, Okamoto Y. |
| Title | The Safety and Anti-Tumor Effects of Ozonated Water in Vivo. |
| Journal | Int J Mol Sci |
| Abstract |
Ozonated water is easier to handle than ozone gas. However, there have been no previous reports on the biological effects of ozonated water. We conducted a study on the safety of ozonated water and its anti-tumor effects using a tumor-bearing mouse model and normal controls. Local administration of ozonated water (208 mM) was not associated with any detrimental effects in normal tissues. On the other hand, local administration of ozonated water (20.8, 41.6, 104, or 208 mM) directly into the tumor tissue induced necrosis and inhibited proliferation of tumor cells. There was no significant difference in the number of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick-end labeling (TUNEL)-positive cells following administration of ozonated water. The size of the necrotic areas was dependent on the concentration of ozonated water. These results indicate that ozonated water does not affect normal tissue and damages only the tumor tissue by selectively inducing necrosis. There is a possibility that it exerts through the production of reaction oxygen species (ROS). In addition, the induction of necrosis rather than apoptosis is very useful in tumor immunity. Based on these results, we believe that administration of ozonated water is a safe and potentially simple adjunct or alternative to existing antineoplastic treatments. |
| Volume | 16(10) |
| Pages | 25108-20 |
| Published | 2015-10-22 |
| DOI | 10.3390/ijms161025108 |
| PII | ijms161025108 |
| PMID | 26506343 |
| PMC | PMC4632793 |
| MeSH | Animals Antineoplastic Agents / adverse effects Antineoplastic Agents / chemistry Antineoplastic Agents / pharmacology* Apoptosis / drug effects Cell Line, Tumor Cell Proliferation / drug effects* DNA Nucleotidylexotransferase / metabolism Female In Situ Nick-End Labeling Mice Mice, Inbred BALB C Necrosis / pathology* Oxygen / chemistry Ozone / adverse effects Ozone / chemistry* Ozone / pharmacology* Reactive Oxygen Species / metabolism Water / chemistry* |
| IF | 4.556 |
| Times Cited | 4 |
| WOS Category | CHEMISTRY, MULTIDISCIPLINARY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 21 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | Colon-26(RCB2657) |