論文 - 詳細
| RRC ID | 38449 |
|---|---|
| 著者 | Shimizu K, Asakura M, Fujii S. |
| タイトル | Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L+ CD4+ memory T cells. |
| ジャーナル | J Immunol |
| Abstract |
Immunotherapy using dendritic cells (DCs) has the potential to activate both T cells and NK cells. We previously demonstrated the long-lasting antitumor responses by NK cells following immunization with bone marrow-derived DCs. In the current study, we demonstrate that long-term antitumor NK responses require endogenous DCs and a subset of effector memory CD4(+) T (CD4(+) T(EM)) cells. One month after DC immunization, injection of a tumor into DC-immunized mice leads to an increase in the expression of CXCL10 by endogenous DCs, thus directing NK cells into the white pulp where the endogenous DCs bridged CD4(+) T(EM) cells and NK cells. In this interaction, CD4(+) T(EM) cells express CD40L, which matures the endogenous DCs, and produce cytokines, such as IL-2, which activates NK cells. These findings suggest that DC vaccination can sustain long-term innate NK cell immunity but requires the participation of the adaptive immune system. |
| 巻・号 | 186(10) |
| ページ | 5927-37 |
| 公開日 | 2011-5-15 |
| DOI | 10.4049/jimmunol.1003351 |
| PII | jimmunol.1003351 |
| PMID | 21460206 |
| MeSH | Adaptive Immunity Animals CD4-Positive T-Lymphocytes / cytology CD4-Positive T-Lymphocytes / immunology* CD4-Positive T-Lymphocytes / metabolism CD40 Ligand / analysis Cancer Vaccines / immunology Cell Line, Tumor Cells, Cultured Chemokine CXCL10 / biosynthesis Chemokine CXCL10 / genetics Chemokine CXCL10 / immunology* Cytokines / biosynthesis Cytokines / immunology Dendritic Cells / cytology Dendritic Cells / immunology* Dendritic Cells / metabolism Immunologic Memory Interleukin-2 / immunology Killer Cells, Natural / immunology* Mice Mice, Inbred C57BL Mice, Knockout Polymerase Chain Reaction Sarcoma, Experimental / immunology* Sarcoma, Experimental / prevention & control Signal Transduction T-Lymphocyte Subsets / immunology* |
| IF | 4.886 |
| 引用数 | 16 |
| WOS 分野 | IMMUNOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |