論文 - 詳細
| RRC ID | 38455 |
|---|---|
| 著者 | Tsolmon S, Nakazaki E, Han J, Isoda H. |
| タイトル | Apigetrin induces erythroid differentiation of human leukemia cells K562: proteomics approach. |
| ジャーナル | Mol Nutr Food Res |
| Abstract |
SCOPE:Induction of cancer-cell differentiation is an alternative approach for cancer chemotherapy. There are numerous studies that diets containing an abundance of fruits and vegetables have protection against cancers, and the main agents thought to provide such protective effect are flavonoids. In this study we used apigetrin as a possible cell differentiation inducer and chronic leukemia cells K562 for their pluripotent differentiating potency. METHODS AND RESULTS:Prolonged treatment with 75 μM apigetrin induced erythroid differentiation of K562 cells with specific marker glycophorin A expression and fetal hemoglobin synthesis in treated cells, which was accompanied with G(2) /M arrest. Proteomics data revealed the downregulation of several proteins expression involved in cell cycle regulation, protein synthesis and nuclear import and export of signaling molecules. CONCLUSION:This is the first evidence that natural compound apigetrin may induce cancer cell differentiation thus could be one of the possible explanations of its antitumor effects. |
| 巻・号 | 55 Suppl 1 |
| ページ | S93-S102 |
| 公開日 | 2011-5-1 |
| DOI | 10.1002/mnfr.201000650 |
| PMID | 21480518 |
| MeSH | Antineoplastic Agents, Phytogenic / pharmacology* Apigenin / pharmacology* Cell Cycle Cell Differentiation / drug effects* Cell Survival Down-Regulation Fetal Hemoglobin / biosynthesis Glycophorins / biosynthesis Humans K562 Cells Leukemia / pathology* Proteomics / methods |
| IF | 5.309 |
| 引用数 | 17 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | K562(RCB0027) |