論文 - 詳細
| RRC ID | 38491 |
|---|---|
| 著者 | Ichihara H, Ueno J, Umebayashi M, Matsumoto Y, Ueoka R. |
| タイトル | Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis in vivo. |
| ジャーナル | Int J Pharm |
| Abstract |
Hybrid liposomes (HL) composed of 95 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 5 mol% polyoxyethylene (25) dodecyl ether (C(12)(EO)(25)) were prepared by sonication. A clear solutions of HL-25 having hydrodynamic diameter of about 50 nm could be maintained over 3 weeks. Remarkable reduction of tumor volume in model mice of acute lymphatic leukemia (ALL) intravenously treated with HL-25 without drugs after the subcutaneously inoculation of human ALL (MOLT-4) cells was verified in vivo. Induction of apoptosis in tumor of model mice of ALL treated with HL-25 was observed in micrographs on the basis of TUNEL method. Remarkable decrease of the ascites in ALL model mice treated with HL-25 was observed. It is noteworthy that prolonged survival (>400%) was obtained in model mice of ALL after the treatment with HL-25 without drugs. |
| 巻・号 | 406(1-2) |
| ページ | 173-8 |
| 公開日 | 2011-3-15 |
| DOI | 10.1016/j.ijpharm.2010.12.041 |
| PII | S0378-5173(11)00015-9 |
| PMID | 21219998 |
| MeSH | Animals Apoptosis / drug effects* Cell Culture Techniques Cell Line, Tumor Dimyristoylphosphatidylcholine / administration & dosage Dimyristoylphosphatidylcholine / chemistry Dimyristoylphosphatidylcholine / therapeutic use* Female Humans In Situ Nick-End Labeling Liposomes Membrane Potential, Mitochondrial / drug effects Mice Mice, SCID Polyethylene Glycols / administration & dosage Polyethylene Glycols / chemistry Polyethylene Glycols / therapeutic use* Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy* Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology Survival Analysis Xenograft Model Antitumor Assays |
| IF | 4.845 |
| 引用数 | 14 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| ヒト・動物細胞 | |