論文 - 詳細
| RRC ID | 38540 |
|---|---|
| 著者 | Yang EJ, Lee JS, Song BB, Yun CY, Kim DH, Kim IS. |
| タイトル | Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice. |
| ジャーナル | J Ethnopharmacol |
| Abstract |
AIM OF THE STUDY:In the present study, we investigated whether the Lagerstroemia indica Linn (LI) extract has an anti-inflammatory effect on lung inflammation in ovalbumin-induced asthmatic mice. MATERIALS AND METHODS:The LI extract was obtained from dried and powdered whole plants of LI using 80% ethanol. ELISA was performed to evaluate cytokine concentration. BALB/c mice were used as a mouse model of asthma after asthmatic induction by ovalbumin sensitization and inhalation. We examined the effects of the LI extract on leukocyte infiltration and mucus secretion using cell count and histological stain. RESULTS:The amount of cytokines, such as interleukin (IL)-2, IL-4, IL-5, IL-13, and TNF-α, was increased in Jurkat cells using the extract from house dust mites. Increased cytokine concentrations were inhibited by the LI extract. The LI extract suppressed the increased expression of IL-6 after treatment with mite extract of EoL-1 cells and THP-1 cells. In an in vivo experiment using asthmatic mice, the LI extract significantly inhibited leukocytosis and eosinophilia in bronchoalveolar lavage (BAL) fluid and lung tissue samples. The LI extract inhibited the increase in mucus secretion by goblet cells, blocked the production of reactive oxygen species in BAL fluid cells, and blocked the protein expression of IL-5 in BAL fluid. The concentration of ovalbumin-specific IgE in BAL fluid was weakly inhibited by the LI extract. CONCLUSIONS:These results suggest that the LI extract may be used as a valuable agent for treating allergic diseases such as asthma due to its anti-inflammatory property. |
| 巻・号 | 136(3) |
| ページ | 422-7 |
| 公開日 | 2011-7-14 |
| DOI | 10.1016/j.jep.2010.05.066 |
| PII | S0378-8741(10)00423-X |
| PMID | 20600763 |
| MeSH | Animals Anti-Inflammatory Agents / pharmacology Anti-Inflammatory Agents / therapeutic use* Asthma / drug therapy* Asthma / immunology Asthma / metabolism Bronchoalveolar Lavage Fluid Cell Line Cytokines / metabolism* Eosinophilia / drug therapy Eosinophils / metabolism Female Goblet Cells / drug effects Humans Immunoglobulin E / metabolism Inflammation / drug therapy* Inflammation / metabolism Lagerstroemia* Leukocytosis / drug therapy Lung / drug effects* Lung / immunology Lung / metabolism Mice Mice, Inbred BALB C Mucus / metabolism Ovalbumin Phytotherapy* Plant Extracts / pharmacology Plant Extracts / therapeutic use Pyroglyphidae Reactive Oxygen Species / metabolism |
| IF | 3.69 |
| 引用数 | 13 |
| WOS 分野 | INTEGRATIVE & COMPLEMENTARY MEDICINE PLANT SCIENCES PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | |