論文 - 詳細
| RRC ID | 38585 |
|---|---|
| 著者 | Tsuruno C, Okuma K, Takahashi Y, Tanaka R, Tanaka Y, Takahama Y, Hamaguchi Y, Hamaguchi I, Yamaguchi K. |
| タイトル | A recombinant vesicular stomatitis virus encoding HIV-1 receptors and human OX40 ligand efficiently eliminates HIV-1-infected CD4-positive T cells expressing OX40. |
| ジャーナル | Hum Immunol |
| Abstract |
OX40 protein is highly expressed on activated CD4-positive T cells that are susceptible for human immunodeficiency virus type 1 (HIV-1) infection. To target and kill HIV-1-infected OX40(+) T cells, we used a recombinant vesicular stomatitis virus (rVSV) lacking its envelope glycoprotein (ΔG) and instead expressing HIV-1 receptors CD4/CXCR4 and OX40 ligand (OX40L). Expression of OX40L as well as HIV-1 receptors on the VSV particles led to specific infection of OX40(+) T cells, including primary cells, either acutely or chronically infected with X4 HIV-1. Consequently, the rVSV rapidly eliminated these infected cells and caused a marked reduction of HIV-1 viral load in culture. Inclusion of the OX40L gene in the VSV recombinant led to significantly better infection and HIV-1 elimination compared with an rVSVΔG expressing only HIV-1 receptors. A novel rVSVΔG encoding both HIV-1 receptors and OX40L has a potentially greater therapeutic value than an rVSVΔG expressing only HIV-1 receptors. |
| 巻・号 | 72(4) |
| ページ | 295-304 |
| 公開日 | 2011-4-1 |
| DOI | 10.1016/j.humimm.2011.01.007 |
| PII | S0198-8859(11)00015-2 |
| PMID | 21262309 |
| MeSH | Animals CD4 Antigens / genetics CD4 Antigens / immunology CD4 Antigens / metabolism CD4-Positive T-Lymphocytes / immunology* CD4-Positive T-Lymphocytes / virology* Cell Line Cell Line, Tumor Cricetinae Gene Order Genetic Vectors / genetics Genetic Vectors / isolation & purification Genetic Vectors / metabolism Giant Cells / metabolism Giant Cells / pathology HEK293 Cells HIV Infections* / immunology HIV Infections* / virology HIV-1 / immunology* HIV-1 / metabolism Humans OX40 Ligand / genetics OX40 Ligand / immunology* Receptors, CXCR4 / genetics Receptors, CXCR4 / immunology Receptors, CXCR4 / metabolism Receptors, OX40 / immunology* Vesiculovirus / genetics Vesiculovirus / isolation & purification Vesiculovirus / metabolism* Viral Load |
| IF | 2.412 |
| 引用数 | 4 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | BHK-21(RCB1423) |