論文 - 詳細
| RRC ID | 38608 |
|---|---|
| 著者 | Fujimoto T, Andoh T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Sonobe H, Epstein AL, Akisue T, Kirihata M, Kurosaka M, Fukumori Y, Ichikawa H. |
| タイトル | Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies. |
| ジャーナル | Appl Radiat Isot |
| Abstract |
Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies. |
| 巻・号 | 69(12) |
| ページ | 1713-6 |
| 公開日 | 2011-12-1 |
| DOI | 10.1016/j.apradiso.2011.02.006 |
| PII | S0969-8043(11)00081-9 |
| PMID | 21354804 |
| MeSH | Animals Boron Compounds / pharmacokinetics* Boron Neutron Capture Therapy* Cell Line, Tumor Humans In Vitro Techniques Melanoma, Experimental / metabolism Microscopy, Electron Phenylalanine / analogs & derivatives* Phenylalanine / pharmacokinetics Sarcoma, Clear Cell / metabolism* |
| IF | 1.27 |
| 引用数 | 8 |
| WOS 分野 | NUCLEAR SCIENCE & TECHNOLOGY CHEMISTRY, INORGANIC & NUCLEAR RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING |
| リソース情報 | |
| ヒト・動物細胞 | B16F10(RCB2630) |