論文 - 詳細
| RRC ID | 38611 |
|---|---|
| 著者 | Mashidori T, Shirataki H, Kamai T, Nakamura F, Yoshida K. |
| タイトル | Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer. |
| ジャーナル | Biomed Res |
| Abstract |
Intracellular vesicle trafficking is the principal transportation system in eukaryotic cells, and is considered to be involved in a variety of processes related to cell proliferation. A protein named alpha-taxilin has been identified as a binding partner of the syntaxin family, which coordinates intracellular vesicle trafficking. To clarify the role of alpha-taxilin in renal cell carcinoma (RCC), we investigated alpha-taxilin protein expression in clear cell RCC tissues. We analyzed alphataxilin protein in matched sets of tumor and non-tumor tissues from the surgical specimens of 52 Japanese RCC patients by Western blotting. We also studied the relation between alpha-taxilin protein expression in tumor tissues and various clinicopathological features. The alpha-taxilin protein level was higher in tumor tissues than in non-tumor tissues (P < 0.05). Increased expression of alpha-taxilin protein in primary tumors was related to local invasion (P < 0.001), pathological vessel invasion (P < 0.001), and metastasis (P < 0.0001). Kaplan-Meier plots of survival for patients with low versus high alpha-taxilin expression revealed that high expression in tumor tissues was associated with shorter overall survival in all patients (P < 0.05) and with shorter disease-free survival in patients without metastasis (P < 0.01). These findings suggest that alpha-taxilin influences the metastatic and invasive potential of RCC. |
| 巻・号 | 32(2) |
| ページ | 103-10 |
| 公開日 | 2011-4-1 |
| DOI | 10.2220/biomedres.32.103 |
| PII | JST.JSTAGE/biomedres/32.103 |
| PMID | 21551945 |
| MeSH | Aged Asian People Biomarkers, Tumor / genetics Biomarkers, Tumor / metabolism Blotting, Western Carcinoma, Renal Cell* Cell Proliferation Disease-Free Survival Female Gene Expression Humans Kaplan-Meier Estimate Kidney Neoplasms / genetics* Kidney Neoplasms / metabolism Kidney Neoplasms / mortality Kidney Neoplasms / pathology Male Middle Aged Neoplasm Invasiveness Prognosis Qa-SNARE Proteins / genetics Qa-SNARE Proteins / metabolism Vesicular Transport Proteins* / genetics Vesicular Transport Proteins* / metabolism |
| IF | 1.429 |
| 引用数 | 14 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293(RCB1637) TUHR4TKB(RCB1198) |