RRC ID 38611
Author Mashidori T, Shirataki H, Kamai T, Nakamura F, Yoshida K.
Title Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.
Journal Biomed Res
Abstract Intracellular vesicle trafficking is the principal transportation system in eukaryotic cells, and is considered to be involved in a variety of processes related to cell proliferation. A protein named alpha-taxilin has been identified as a binding partner of the syntaxin family, which coordinates intracellular vesicle trafficking. To clarify the role of alpha-taxilin in renal cell carcinoma (RCC), we investigated alpha-taxilin protein expression in clear cell RCC tissues. We analyzed alphataxilin protein in matched sets of tumor and non-tumor tissues from the surgical specimens of 52 Japanese RCC patients by Western blotting. We also studied the relation between alpha-taxilin protein expression in tumor tissues and various clinicopathological features. The alpha-taxilin protein level was higher in tumor tissues than in non-tumor tissues (P < 0.05). Increased expression of alpha-taxilin protein in primary tumors was related to local invasion (P < 0.001), pathological vessel invasion (P < 0.001), and metastasis (P < 0.0001). Kaplan-Meier plots of survival for patients with low versus high alpha-taxilin expression revealed that high expression in tumor tissues was associated with shorter overall survival in all patients (P < 0.05) and with shorter disease-free survival in patients without metastasis (P < 0.01). These findings suggest that alpha-taxilin influences the metastatic and invasive potential of RCC.
Volume 32(2)
Pages 103-10
Published 2011-4-1
DOI 10.2220/biomedres.32.103
PII JST.JSTAGE/biomedres/32.103
PMID 21551945
MeSH Aged Asian People Biomarkers, Tumor / genetics Biomarkers, Tumor / metabolism Blotting, Western Carcinoma, Renal Cell* Cell Proliferation Disease-Free Survival Female Gene Expression Humans Kaplan-Meier Estimate Kidney Neoplasms / genetics* Kidney Neoplasms / metabolism Kidney Neoplasms / mortality Kidney Neoplasms / pathology Male Middle Aged Neoplasm Invasiveness Prognosis Qa-SNARE Proteins / genetics Qa-SNARE Proteins / metabolism Vesicular Transport Proteins* / genetics Vesicular Transport Proteins* / metabolism
IF 1.429
Times Cited 14
Human and Animal Cells 293(RCB1637) TUHR4TKB(RCB1198)