| RRC ID |
38611
|
| 著者 |
Mashidori T, Shirataki H, Kamai T, Nakamura F, Yoshida K.
|
| タイトル |
Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.
|
| ジャーナル |
Biomed Res
|
| Abstract |
Intracellular vesicle trafficking is the principal transportation system in eukaryotic cells, and is considered to be involved in a variety of processes related to cell proliferation. A protein named alpha-taxilin has been identified as a binding partner of the syntaxin family, which coordinates intracellular vesicle trafficking. To clarify the role of alpha-taxilin in renal cell carcinoma (RCC), we investigated alpha-taxilin protein expression in clear cell RCC tissues. We analyzed alphataxilin protein in matched sets of tumor and non-tumor tissues from the surgical specimens of 52 Japanese RCC patients by Western blotting. We also studied the relation between alpha-taxilin protein expression in tumor tissues and various clinicopathological features. The alpha-taxilin protein level was higher in tumor tissues than in non-tumor tissues (P < 0.05). Increased expression of alpha-taxilin protein in primary tumors was related to local invasion (P < 0.001), pathological vessel invasion (P < 0.001), and metastasis (P < 0.0001). Kaplan-Meier plots of survival for patients with low versus high alpha-taxilin expression revealed that high expression in tumor tissues was associated with shorter overall survival in all patients (P < 0.05) and with shorter disease-free survival in patients without metastasis (P < 0.01). These findings suggest that alpha-taxilin influences the metastatic and invasive potential of RCC.
|
| 巻・号 |
32(2)
|
| ページ |
103-10
|
| 公開日 |
2011-4-1
|
| DOI |
10.2220/biomedres.32.103
|
| PII |
JST.JSTAGE/biomedres/32.103
|
| PMID |
21551945
|
| MeSH |
Aged
Asian People
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Blotting, Western
Carcinoma, Renal Cell*
Cell Proliferation
Disease-Free Survival
Female
Gene Expression
Humans
Kaplan-Meier Estimate
Kidney Neoplasms / genetics*
Kidney Neoplasms / metabolism
Kidney Neoplasms / mortality
Kidney Neoplasms / pathology
Male
Middle Aged
Neoplasm Invasiveness
Prognosis
Qa-SNARE Proteins / genetics
Qa-SNARE Proteins / metabolism
Vesicular Transport Proteins* / genetics
Vesicular Transport Proteins* / metabolism
|
| IF |
1.429
|
| 引用数 |
14
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
|
| リソース情報 |
| ヒト・動物細胞 |
293(RCB1637)
TUHR4TKB(RCB1198) |
