| RRC ID |
38629
|
| Author |
Tanaka Y, Tsuyuki M, Itaya-Hironaka A, Inada Y, Yoshihara K, Kamiya T.
|
| Title |
Retinoic acid-induced differentiation-specific, C-kinase-dependent phosphorylation of cytosolic 44 and 32 kDa proteins in HL-60 cells.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
The effect of various differentiation-inducers on the activity of Ca2+, phospholipid-dependent protein kinase (C-kinase) activity and endogenous protein phosphorylation by the kinase were examined in the extracts of HL-60 cells. Although all of the inducers, retinoic acid, dibutyryl cAMP, nicotinamide, dimethylsulfoxide, and 3-aminobenzamide increased the cytosolic C-kinase activity accompanied with the differentiation into mature myelocytes, only retinoic acid markedly enhanced Ca2+, phospholipid-dependent phosphorylation of 44 and 32 kDa proteins in the cytosol. These results suggest that the differentiation pathway induced by retinoic acid is different from the pathways induced by other inducers.
|
| Volume |
168(3)
|
| Pages |
1253-60
|
| Published |
1990-5-16
|
| DOI |
10.1016/0006-291x(90)91163-m
|
| PII |
0006-291X(90)91163-M
|
| PMID |
2161220
|
| MeSH |
Benzamides / pharmacology
Bucladesine / pharmacology
Calcium / metabolism
Cell Differentiation / drug effects*
Cell Extracts
Cells, Cultured
Cytosol / enzymology
Dimethyl Sulfoxide / pharmacology
Electrophoresis, Polyacrylamide Gel
Humans
Molecular Weight
Niacinamide / pharmacology
Phosphorylation
Protein Kinase C / metabolism*
Proteins / metabolism*
Tretinoin / pharmacology*
|
| IF |
2.985
|
| Times Cited |
16
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
HL60(RCB0041) |
