Reference - Detail
| RRC ID | 38633 |
|---|---|
| Author | Yanagida M, Gohda E, Yamamoto I. |
| Title | Dibutyrylcytidine 3',5'-cyclic monophosphate stimulates neurite outgrowth in rat pheochromocytoma PC12. |
| Journal | Neurosci Lett |
| Abstract |
Dibutyrylcytidine 3',5'-cyclic monophosphate (Bt2cCMP) stimulated neurite outgrowth in rat pheochromocytoma PC12 cells in a dose-dependent manner at the dose range from 0.5 mM to 6 mM. About 25% of the cells had neurites in response to 6 mM Bt2cCMP. In contrast with the effect of nerve growth factor (NGF) which increased the percentage of cells with neurites gradually during a 6-day culture period, the stimulating effect of Bt2cCMP reached a plateau 2 days after plating. Staurosporine inhibited the neurite outgrowth induced by NGF, but not that by Bt2cCMP. These results suggest that Bt2cCMP stimulates neuronal differentiation by a mechanism different from that by NGF. |
| Volume | 114(3) |
| Pages | 323-8 |
| Published | 1990-7-13 |
| DOI | 10.1016/0304-3940(90)90584-v |
| PII | 0304-3940(90)90584-V |
| PMID | 2169600 |
| MeSH | Adrenal Gland Neoplasms Animals Axons / drug effects Axons / physiology* Cyclic CMP / analogs & derivatives Cyclic CMP / pharmacology* Cytosine Nucleotides / pharmacology* Nerve Growth Factors / pharmacology Pheochromocytoma Rats |
| IF | 2.274 |
| Times Cited | 5 |
| WOS Category | NEUROSCIENCES |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |