Reference - Detail
| RRC ID | 38641 |
|---|---|
| Author | Shioi A, Teitelbaum SL, Ross FP, Welgus HG, Suzuki H, Ohara J, Lacey DL. |
| Title | Interleukin 4 inhibits murine osteoclast formation in vitro. |
| Journal | J Cell Biochem |
| Abstract |
Interleukin 4 (IL-4) is a product of activated T cells and mast cells with effects on immunologic and hematopoietic processes. We now report that IL-4 inhibits the formation of osteoclasts from murine bone marrow cells cocultured with stromal cells. Numerous (3,000-4,000 cells/2 cm2) tartrate-resistant acid-phosphatase-positive multinucleated cells with the capacity to generate cAMP in response to salmon calcitonin (ED50 = 10(-10) M) developed within 10-12 days of culture. IL-4 (ID50 = 10 U/ml) inhibited osteoclast generation in doses similar to those that induce proliferation of IL-4-responsive T cells. Additionally, the rat antimurine IL-4 monoclonal antibody 11B11 antagonizes the IL-4-inhibitory effect on osteoclast formation. These results suggest that IL-4 impedes agonist-induced in vitro bone resorption by inhibiting osteoclastogenesis. |
| Volume | 47(3) |
| Pages | 272-7 |
| Published | 1991-11-1 |
| DOI | 10.1002/jcb.240470313 |
| PMID | 1665152 |
| MeSH | Animals Antibodies, Monoclonal Biomarkers Bone Marrow / drug effects* Bone Marrow Cells Bone Remodeling / physiology Calcitonin / pharmacology Cell Differentiation / drug effects Cell Division Cells, Cultured Cyclic AMP / metabolism Interleukin-4 / immunology Interleukin-4 / pharmacology* Lymphocyte Activation / physiology Mice Osteoclasts / drug effects* T-Lymphocytes / cytology T-Lymphocytes / drug effects |
| IF | 4.237 |
| Times Cited | 74 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | ST2(RCB0224) |