論文 - 詳細
| RRC ID | 38659 |
|---|---|
| 著者 | Gohda E, Matsunaga T, Kataoka H, Yamamoto I. |
| タイトル | TGF-beta is a potent inhibitor of hepatocyte growth factor secretion by human fibroblasts. |
| ジャーナル | Cell Biol Int Rep |
| Abstract |
Transforming growth factor-beta 1 (TGF-beta 1) inhibited secretion of human hepatocyte growth factor (hHGF), which is also known as scatter factor or fibroblast-derived tumor cytotoxic factor, by MRC-5 cells. The effect was detectable at as little as 10 pg/ml and was more potent than that of dexamethasone. Complete inhibition was observed after 12 h in the presence of 5 ng/ml of TGF-beta 1. Phorbol 12-myristate 13-acetate-induced secretion of hHGF from human skin fibroblasts was also suppressed by TGF-beta 1. TGF-beta 2 inhibited hHGF secretion by MRC-5 cells to the same extent as TGF-beta 1, but other growth factors such as epidermal growth factor and acidic and basic fibroblast growth factors had only a slight or null inhibitory effect. |
| 巻・号 | 16(9) |
| ページ | 917-26 |
| 公開日 | 1992-9-1 |
| DOI | 10.1016/s0309-1651(06)80171-2 |
| PMID | 1423659 |
| MeSH | Cell Division Cell Line Dexamethasone / pharmacology Dose-Response Relationship, Drug Fibroblasts / drug effects* Fibroblasts / metabolism Hepatocyte Growth Factor / metabolism* Humans Liver / drug effects Liver / metabolism Liver Regeneration Skin / drug effects Skin / metabolism Transforming Growth Factor beta / pharmacology* |
| 引用数 | 63 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | MRC-5 |