RRC ID 38691
著者 Quinn JM, Athanasou NA.
タイトル Tumour infiltrating macrophages are capable of bone resorption.
ジャーナル J Cell Sci
Abstract The cell types responsible for osteolysis associated with skeletal metastasis of solid malignancies are unclear. Tumour infiltrating macrophages (TIMs) isolated from primary mammary carcinomas of C3H/Avy mice were cultured on bone slices to assess their ability to resorb bone. After 14 days in co-culture with murine marrow stromal cell line ST2 and added 1,25-dihydroxyvitamin D3 and dexamethasone, TIMs showed increased tartrate-resistant acid phosphatase activity and formed numerous lacunar resorption pits. In the absence of ST2 cells, TIMs did not form lacunar resorption pits but produced roughening of the bone surface with exposure of mineralized collagen fibres. Normal alveolar macrophages, in both the presence and absence of ST2 cells similarly produced only surface resorption. TIMs are thus capable of both low-grade (surface) and high-grade (lacunar) pathological bone resorption, a specific interaction with stromal cells being necessary for the latter to occur. TIM-mediated bone resorption could account for different clinical and pathological patterns of tumour osteolysis.
巻・号 101 ( Pt 3)
ページ 681-6
公開日 1992-3-1
DOI 10.1242/jcs.101.3.681
PMID 1522150
MeSH Animals Bone Resorption* Cells, Cultured Macrophages / physiology* Macrophages, Alveolar / physiology Mammary Neoplasms, Experimental / immunology* Mice Mice, Inbred C3H
IF 4.573
引用数 32
WOS 分野 CELL BIOLOGY
リソース情報
ヒト・動物細胞 ST2(RCB0224)