論文 - 詳細
| RRC ID | 38697 |
|---|---|
| 著者 | Konno S, Adachi M, Asano K, Gonogami Y, Ikeda K, Okamoto K, Takahashi T. |
| タイトル | Suppressive effects of IPD-1151T (suplatast-tosilate) on induction of mast cells from normal mouse splenocytes. |
| ジャーナル | Eur J Pharmacol |
| Abstract |
The influence of IPD-1151T (suplatast-tosilate) on murine mast cell induction was examined by in vitro cell culture. Splenocytes from BALB/c mice suspended in RPMI-1640 medium supplemented with interleukin-3 were cultured in the presence or absence of IPD-1151T. Half of the total volume of the medium was changed every 4-5 days. The number of mast cells increased with culture time and reached a peak on the 16th day when the cells were cultured without IPD-1151T. However, the growth of mast cells from the splenocyte culture was dose dependently inhibited by IPD-1151T. Furthermore, IPD-1151T inhibited the proliferation of mast cell progenitor cells, IC-2, but not that of splenocytes or mature mast cells. |
| 巻・号 | 259(1) |
| ページ | 15-20 |
| 公開日 | 1994-6-23 |
| DOI | 10.1016/0014-2999(94)90151-1 |
| PII | 0014-2999(94)90151-1 |
| PMID | 7957588 |
| MeSH | Animals Arylsulfonates / pharmacokinetics Arylsulfonates / pharmacology* Cell Division / drug effects Cells, Cultured Cromolyn Sodium / pharmacology Histamine Antagonists / pharmacology* Male Mast Cells / drug effects* Mice Mice, Inbred BALB C Spleen / cytology Sulfonium Compounds / pharmacokinetics Sulfonium Compounds / pharmacology* |
| IF | 3.263 |
| 引用数 | 14 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | IC-2(RCB0102) |