| RRC ID |
38697
|
| 著者 |
Konno S, Adachi M, Asano K, Gonogami Y, Ikeda K, Okamoto K, Takahashi T.
|
| タイトル |
Suppressive effects of IPD-1151T (suplatast-tosilate) on induction of mast cells from normal mouse splenocytes.
|
| ジャーナル |
Eur J Pharmacol
|
| Abstract |
The influence of IPD-1151T (suplatast-tosilate) on murine mast cell induction was examined by in vitro cell culture. Splenocytes from BALB/c mice suspended in RPMI-1640 medium supplemented with interleukin-3 were cultured in the presence or absence of IPD-1151T. Half of the total volume of the medium was changed every 4-5 days. The number of mast cells increased with culture time and reached a peak on the 16th day when the cells were cultured without IPD-1151T. However, the growth of mast cells from the splenocyte culture was dose dependently inhibited by IPD-1151T. Furthermore, IPD-1151T inhibited the proliferation of mast cell progenitor cells, IC-2, but not that of splenocytes or mature mast cells.
|
| 巻・号 |
259(1)
|
| ページ |
15-20
|
| 公開日 |
1994-6-23
|
| DOI |
10.1016/0014-2999(94)90151-1
|
| PII |
0014-2999(94)90151-1
|
| PMID |
7957588
|
| MeSH |
Animals
Arylsulfonates / pharmacokinetics
Arylsulfonates / pharmacology*
Cell Division / drug effects
Cells, Cultured
Cromolyn Sodium / pharmacology
Histamine Antagonists / pharmacology*
Male
Mast Cells / drug effects*
Mice
Mice, Inbred BALB C
Spleen / cytology
Sulfonium Compounds / pharmacokinetics
Sulfonium Compounds / pharmacology*
|
| IF |
3.263
|
| 引用数 |
14
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ヒト・動物細胞 |
IC-2(RCB0102) |
