RRC ID 38765
Author Moriyama T, Kataoka H, Tsubouchi H, Koono M.
Title Concomitant expression of hepatocyte growth factor (HGF), HGF activator and c-met genes in human glioma cells in vitro.
Journal FEBS Lett
Abstract Three new cell lines of human glioblastoma have been established. These cells co-expressed hepatocyte growth factor (HGF) and its receptor, c-Met, genes in vitro. Reverse-transcriptase/polymerase-chain reaction study revealed that the cells also expressed gene for HGF activator, a recently cloned serine proteinase, suggesting that HGF might have a role in glioma cells in vitro as an autocrine factor. The activator mRNA was also detected in other well-established glioma cell lines, glioma tissues and normal brain. The concomitant expression of HGF, HGF activator and c-met was also detected in one glioblastoma case in vivo out of five tested.
Volume 372(1)
Pages 78-82
Published 1995-9-18
DOI 10.1016/0014-5793(95)00949-a
PII 0014-5793(95)00949-A
PMID 7556648
MeSH Base Sequence DNA Primers Gene Expression* Glioblastoma / genetics Glioblastoma / metabolism* Hepatocyte Growth Factor / genetics* Hepatocyte Growth Factor / metabolism Humans Male Middle Aged Molecular Sequence Data Proto-Oncogene Proteins c-met RNA, Messenger / genetics RNA, Messenger / metabolism Receptor Protein-Tyrosine Kinases / genetics* Serine Endopeptidases / genetics* Tumor Cells, Cultured Urokinase-Type Plasminogen Activator / metabolism
IF 3.057
Times Cited 67
Human and Animal Cells KG-1-C(RCB0270)