論文 - 詳細
RRC ID | 38765 |
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著者 | Moriyama T, Kataoka H, Tsubouchi H, Koono M. |
タイトル | Concomitant expression of hepatocyte growth factor (HGF), HGF activator and c-met genes in human glioma cells in vitro. |
ジャーナル | FEBS Lett |
Abstract |
Three new cell lines of human glioblastoma have been established. These cells co-expressed hepatocyte growth factor (HGF) and its receptor, c-Met, genes in vitro. Reverse-transcriptase/polymerase-chain reaction study revealed that the cells also expressed gene for HGF activator, a recently cloned serine proteinase, suggesting that HGF might have a role in glioma cells in vitro as an autocrine factor. The activator mRNA was also detected in other well-established glioma cell lines, glioma tissues and normal brain. The concomitant expression of HGF, HGF activator and c-met was also detected in one glioblastoma case in vivo out of five tested. |
巻・号 | 372(1) |
ページ | 78-82 |
公開日 | 1995-9-18 |
DOI | 10.1016/0014-5793(95)00949-a |
PII | 0014-5793(95)00949-A |
PMID | 7556648 |
MeSH | Base Sequence DNA Primers Gene Expression* Glioblastoma / genetics Glioblastoma / metabolism* Hepatocyte Growth Factor / genetics* Hepatocyte Growth Factor / metabolism Humans Male Middle Aged Molecular Sequence Data Proto-Oncogene Proteins c-met RNA, Messenger / genetics RNA, Messenger / metabolism Receptor Protein-Tyrosine Kinases / genetics* Serine Endopeptidases / genetics* Tumor Cells, Cultured Urokinase-Type Plasminogen Activator / metabolism |
IF | 3.057 |
引用数 | 67 |
WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
リソース情報 | |
ヒト・動物細胞 | KG-1-C(RCB0270) |