論文 - 詳細
| RRC ID | 38790 |
|---|---|
| 著者 | Miyagi Y, Sugiyama A, Asai A, Okazaki T, Kuchino Y, Kerr SJ. |
| タイトル | Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines. |
| ジャーナル | Cancer Lett |
| Abstract |
Translation initiation factor eIF-4E, which binds to the 5' cap structure of eukaryotic mRNAs, is believed to play an important role in the control of cell growth. Over-expression of eIF-4E in fibroblasts results in their malignant transformation. However, no information on eIF-4E expression in established transformed cell lines has been available. We report here that a variety of tumor cell lines, chemically, virally and oncogenically transformed, exhibit elevated levels of eIF-4E mRNA expression as compared to their normal counterparts. Overexpression of eIF-4E, which is normally rate-limiting in protein synthesis, may stimulate the translation of regulatory and oncogenic proteins involved in transformation. |
| 巻・号 | 91(2) |
| ページ | 247-52 |
| 公開日 | 1995-5-8 |
| DOI | 10.1016/0304-3835(95)03737-h |
| PII | 030438359503737H |
| PMID | 7767916 |
| MeSH | Animals Base Sequence Cell Line Cell Transformation, Neoplastic* DNA Primers / chemistry Eukaryotic Initiation Factor-4E Gene Expression Regulation, Neoplastic* In Vitro Techniques Molecular Sequence Data Peptide Initiation Factors / genetics* RNA, Messenger / genetics RNA, Neoplasm / genetics Rats |
| IF | 7.36 |
| 引用数 | 63 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | SV-3Y1-C66(RCB0343) Py-3Y1-S2(RCB0350) Ad12-3Y1 E1A-3Y1-1(RCB0334) |