| RRC ID |
38790
|
| 著者 |
Miyagi Y, Sugiyama A, Asai A, Okazaki T, Kuchino Y, Kerr SJ.
|
| タイトル |
Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
Translation initiation factor eIF-4E, which binds to the 5' cap structure of eukaryotic mRNAs, is believed to play an important role in the control of cell growth. Over-expression of eIF-4E in fibroblasts results in their malignant transformation. However, no information on eIF-4E expression in established transformed cell lines has been available. We report here that a variety of tumor cell lines, chemically, virally and oncogenically transformed, exhibit elevated levels of eIF-4E mRNA expression as compared to their normal counterparts. Overexpression of eIF-4E, which is normally rate-limiting in protein synthesis, may stimulate the translation of regulatory and oncogenic proteins involved in transformation.
|
| 巻・号 |
91(2)
|
| ページ |
247-52
|
| 公開日 |
1995-5-8
|
| DOI |
10.1016/0304-3835(95)03737-h
|
| PII |
030438359503737H
|
| PMID |
7767916
|
| MeSH |
Animals
Base Sequence
Cell Line
Cell Transformation, Neoplastic*
DNA Primers / chemistry
Eukaryotic Initiation Factor-4E
Gene Expression Regulation, Neoplastic*
In Vitro Techniques
Molecular Sequence Data
Peptide Initiation Factors / genetics*
RNA, Messenger / genetics
RNA, Neoplasm / genetics
Rats
|
| IF |
7.36
|
| 引用数 |
63
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
SV-3Y1-C66(RCB0343)
Py-3Y1-S2(RCB0350)
Ad12-3Yl
E1A-3Y1-1(RCB0334) |
