RRC ID 3888
Author Nakamura H, Kimura T, Koyama S, Ogita K, Tsutsui T, Shimoya K, Taniguchi T, Koyama M, Kaneda Y, Murata Y.
Title Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure.
Journal FEBS Lett.
Abstract Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure.
Volume 580(11)
Pages 2717-22
Published 2006-5-15
DOI 10.1016/j.febslet.2006.04.029
PII S0014-5793(06)00451-0
PMID 16647058
MeSH Animals Disease Models, Animal* Embryo Implantation* Embryo Loss / metabolism* Embryo Loss / pathology Embryo Loss / physiopathology Endometrium / metabolism* Endometrium / pathology Female Humans Infertility / metabolism* Infertility / pathology Male Mice Mice, Inbred ICR Ovary / physiology Pregnancy STAT3 Transcription Factor / genetics STAT3 Transcription Factor / metabolism*
IF 2.675
Times Cited 43
WOS Category BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
Resource
DNA material pEF-Flag-mSTATY705F (RDB02354)