| RRC ID |
3888
|
| Author |
Nakamura H, Kimura T, Koyama S, Ogita K, Tsutsui T, Shimoya K, Taniguchi T, Koyama M, Kaneda Y, Murata Y.
|
| Title |
Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure.
|
| Journal |
FEBS Lett
|
| Abstract |
Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure.
|
| Volume |
580(11)
|
| Pages |
2717-22
|
| Published |
2006-5-15
|
| DOI |
10.1016/j.febslet.2006.04.029
|
| PII |
S0014-5793(06)00451-0
|
| PMID |
16647058
|
| MeSH |
Animals
Disease Models, Animal*
Embryo Implantation*
Embryo Loss / metabolism*
Embryo Loss / pathology
Embryo Loss / physiopathology
Endometrium / metabolism*
Endometrium / pathology
Female
Humans
Infertility / metabolism*
Infertility / pathology
Male
Mice
Mice, Inbred ICR
Ovary / physiology
Pregnancy
STAT3 Transcription Factor / genetics
STAT3 Transcription Factor / metabolism*
|
| IF |
3.057
|
| Times Cited |
50
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| DNA material |
pEF-Flag-mSTATY705F (RDB02354) |
