RRC ID 38905
Author Shi YH, Zhu S, Ge YW, He YM, Kazuma K, Wang Z, Yoshimatsu K, Komatsu K.
Title Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.
Journal Fitoterapia
Abstract The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.
Volume 108
Pages 55-61
Published 2016-1-1
DOI 10.1016/j.fitote.2015.11.011
PII S0367-326X(15)30120-9
PMID 26598138
MeSH Animals Anti-Allergic Agents / isolation & purification Anti-Allergic Agents / pharmacology* Cell Line, Tumor Molecular Structure Monoterpenes / isolation & purification Monoterpenes / pharmacology* Paeonia / chemistry* Plant Extracts / chemistry Plant Roots / chemistry* Rats
IF 2.527
Times Cited 18
Human and Animal Cells RBL 2H3(RCB2782)