論文 - 詳細
| RRC ID | 38905 |
|---|---|
| 著者 | Shi YH, Zhu S, Ge YW, He YM, Kazuma K, Wang Z, Yoshimatsu K, Komatsu K. |
| タイトル | Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora. |
| ジャーナル | Fitoterapia |
| Abstract |
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed. |
| 巻・号 | 108 |
| ページ | 55-61 |
| 公開日 | 2016-1-1 |
| DOI | 10.1016/j.fitote.2015.11.011 |
| PII | S0367-326X(15)30120-9 |
| PMID | 26598138 |
| MeSH | Animals Anti-Allergic Agents / isolation & purification Anti-Allergic Agents / pharmacology* Cell Line, Tumor Molecular Structure Monoterpenes / isolation & purification Monoterpenes / pharmacology* Paeonia / chemistry* Plant Extracts / chemistry Plant Roots / chemistry* Rats |
| IF | 2.527 |
| 引用数 | 18 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RBL 2H3(RCB2782) |